MAP3K13 and GLO1

Data Source:
BioGRID (two hybrid)

		MAP3K13	GLO1
Description		mitogen-activated protein kinase kinase kinase 13	glyoxalase I
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding IkappaB Kinase Complex Binding	Lactoylglutathione Lyase Activity Protein Binding Zinc Ion Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Positive Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve	Carbohydrate Metabolic Process Pyruvate Metabolic Process Regulation Of Transcription By RNA Polymerase II Glutathione Metabolic Process Methylglyoxal Metabolic Process Osteoclast Differentiation Negative Regulation Of Apoptotic Process
Pathways			Pyruvate metabolism
Drugs		Fostamatinib	Glutathione Indomethacin S-P-Nitrobenzyloxycarbonylglutathione S-(N-hydroxy-N-iodophenylcarbamoyl)glutathione Mercaptoethanol S-benzylglutathione S-Hexylglutathione methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
Diseases
GWAS		Airflow obstruction ( 22837378) Arterial stiffness index ( 31235810) Major depressive disorder ( 27519822)	Blood protein levels ( 30072576) Major depressive disorder ( 29317602) Restless legs syndrome ( 29029846)
Interacting Genes		8 interacting genes: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25	4 interacting genes: IKBKG MAP3K13 MEOX2 PJA1
Entrez ID		9175	2739
HPRD ID		05372	00730
Ensembl ID		ENSG00000073803	ENSG00000124767
Uniprot IDs		O43283	Q04760 X5DNM4
PDB IDs			1BH5 1FRO 1QIN 1QIP 3VW9 3W0T 3W0U
Enriched GO Terms of Interacting Partners?
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