NPFFR2 and TMEM218

Data Source:
BioGRID (two hybrid)

		NPFFR2	TMEM218
Description		neuropeptide FF receptor 2	transmembrane protein 218
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton	Cilium Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Activity Neuropeptide Receptor Activity Opioid Receptor Binding Peptide Binding	Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Detection Of Abiotic Stimulus Regulation Of MAPK Cascade Regulation Of Adenylate Cyclase Activity Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs
Diseases
GWAS			Breast cancer (survival) ( 25890600) Familial lung adenocarcinoma ( 29924316)
Interacting Genes		6 interacting genes: FKBP7 HCRT NPFF NPY TMEM218 TRARG1	72 interacting genes: APH1A AQP2 AQP6 ARL13B ASZ1 ATP6V0E1 BSCL2 CD300A CD53 CD79A CLDN2 CLEC10A CLEC17A CPLX4 CREB3L1 CTLA4 DAGLA EBP ELOVL2 ELOVL4 EMP1 ERGIC3 FAM209A FCER1G FRMD3 GDAP1 GJB1 GJB4 GJB6 GPR152 GPR61 GPX8 IFNGR2 KCNJ6 KCNK5 KIR2DL3 LDLRAD1 LHFPL5 LMNA LSMEM2 MFF MS4A3 MTIF3 NPFFR2 PCNA PDCD1LG2 PIK3IP1 PLEKHO1 PSCA RETREG3 SAR1A SDC3 SLC10A4 SLC10A6 SLC18A1 SMIM3 SSMEM1 TM4SF18 TMED8 TMEM106C TMEM182 TMEM207 TMEM234 TMEM31 TMEM45B TMEM52B TMEM88 TMPRSS2 TRHR TSPAN12 TSPAN18 VSIR
Entrez ID		10886	219854
HPRD ID		16244	19054
Ensembl ID		ENSG00000056291	ENSG00000150433
Uniprot IDs		A0PJM9 Q9Y5X5	A2RU14
PDB IDs
Enriched GO Terms of Interacting Partners?
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