TMEM218 and DAGLA

Data Source:
BioGRID (two hybrid)

		TMEM218	DAGLA
Description		transmembrane protein 218	diacylglycerol lipase alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cilium Integral Component Of Membrane	Plasma Membrane Early Endosome Membrane Dendrite Membrane Dendritic Spine Membrane Varicosity Postsynaptic Membrane Postsynaptic Density Membrane Integral Component Of Postsynaptic Membrane
	Molecular Function	Protein Binding	Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process		G Protein-coupled Glutamate Receptor Signaling Pathway Neuroblast Proliferation Arachidonic Acid Metabolic Process Neurogenesis Neurotransmitter Biosynthetic Process Diacylglycerol Catabolic Process Endocannabinoid Signaling Pathway Retrograde Trans-synaptic Signaling By Endocannabinoid Regulation Of Neuroinflammatory Response
Pathways			Arachidonate production from DAG
Drugs
Diseases
GWAS		Breast cancer (survival) ( 25890600) Familial lung adenocarcinoma ( 29924316)	Bipolar disorder ( 28115744 31043756) Immune reponse to smallpox (secreted IL-2) ( 22610502) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)
Interacting Genes		72 interacting genes: APH1A AQP2 AQP6 ARL13B ASZ1 ATP6V0E1 BSCL2 CD300A CD53 CD79A CLDN2 CLEC10A CLEC17A CPLX4 CREB3L1 CTLA4 DAGLA EBP ELOVL2 ELOVL4 EMP1 ERGIC3 FAM209A FCER1G FRMD3 GDAP1 GJB1 GJB4 GJB6 GPR152 GPR61 GPX8 IFNGR2 KCNJ6 KCNK5 KIR2DL3 LDLRAD1 LHFPL5 LMNA LSMEM2 MFF MS4A3 MTIF3 NPFFR2 PCNA PDCD1LG2 PIK3IP1 PLEKHO1 PSCA RETREG3 SAR1A SDC3 SLC10A4 SLC10A6 SLC18A1 SMIM3 SSMEM1 TM4SF18 TMED8 TMEM106C TMEM182 TMEM207 TMEM234 TMEM31 TMEM45B TMEM52B TMEM88 TMPRSS2 TRHR TSPAN12 TSPAN18 VSIR	10 interacting genes: CMTM7 LHFPL5 MAL MALL MS4A13 STOM TMEM218 TRARG1 UPK1B VMA21
Entrez ID		219854	747
HPRD ID		19054	07092
Ensembl ID		ENSG00000150433	ENSG00000134780
Uniprot IDs		A2RU14	Q9Y4D2
PDB IDs
Enriched GO Terms of Interacting Partners?
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