HBS1L and EXOSC4

Data Source:
BioGRID (pull down)

		HBS1L	EXOSC4
Description		HBS1 like translational GTPase	exosome component 4
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GO Annotations	Cellular Component	Cytosol Membrane Extracellular Exosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin Intracellular Membrane-bounded Organelle
	Molecular Function	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Translation Translational Elongation Signal Transduction Exonucleolytic Catabolism Of Deadenylated MRNA	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		mRNA decay by 3' to 5' exoribonuclease	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 29403010) Beta thalassemia/hemoglobin E disease ( 20183929) Cholesterol, total ( 24097068) Eosinophil counts ( 29403010 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736) Granulocyte count ( 27863252) HbA2 levels ( 23043469) Hematocrit ( 29403010 32888494 27863252 28017375 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hodgkin's lymphoma ( 24149102) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549 28334899) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 23263863 29403010 32888494 19853236 28453575 20139978 27863252 28017375 28548082 19862010 28031487) Mean corpuscular hemoglobin concentration ( 23263863 29403010 32888494 20139978 27863252 28017375) Mean corpuscular volume ( 23263863 29403010 32888494 19853236 28453575 20139978 27863252 28017375 19862010 28031487) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Other erythrocyte phenotypes ( 19862010) Platelet count ( 26805783 22139419 24026423 29066854 29403010 32888494 19853236 22423221 20139978 27863252 28031487) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010 32888494 28453575 20139978 27863252 28017375 28031487) Red blood cell traits ( 20927387 23935956 23222517) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 30275531) White blood cell count ( 29403010 32888494 20139978 27863252) White blood cell types ( 21738478)	Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		10 interacting genes: APP EXOSC4 EXOSC5 EXOSC6 EXOSC9 MAP3K1 PELO SRPK1 SRPK2 UBE2G2	33 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HBS1L HNRNPD LNX1 LRRC8D MPZL1 MTREX NEK1 PALS2 POLE2 PPARA PTEN SDCBP SKIV2L SMPD4 TSEN15 UPF1 UPF2 UPF3B
Entrez ID		10767	54512
HPRD ID		06582	16221
Ensembl ID		ENSG00000112339	ENSG00000178896
Uniprot IDs		D9YZV0 Q9Y450	Q9NPD3
PDB IDs		5LZW 5LZX 5LZY 5LZZ	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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