EXOSC4 and MPZL1

Data Source:
HPRD (two hybrid)

		EXOSC4	MPZL1
Description		exosome component 4	myelin protein zero like 1
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin Intracellular Membrane-bounded Organelle	Integral Component Of Plasma Membrane Focal Adhesion Cell Surface
	Molecular Function	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding	Structural Molecule Activity Protein Binding
	Biological Process	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Alzheimer's disease (late onset) ( 22881374) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		33 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HBS1L HNRNPD LNX1 LRRC8D MPZL1 MTREX NEK1 PALS2 POLE2 PPARA PTEN SDCBP SKIV2L SMPD4 TSEN15 UPF1 UPF2 UPF3B	10 interacting genes: DOK7 EXOSC4 FBXO7 FHL3 MFF PTPN11 SRC STAT3 TRIM55 TRIM63
Entrez ID		54512	9019
HPRD ID		16221	05086
Ensembl ID		ENSG00000178896	ENSG00000197965
Uniprot IDs		Q9NPD3	A0A024R8Y3 A8K5D4 O95297
PDB IDs		2NN6 6D6Q 6D6R 6H25	6IGO 6IGT 6IGW
Enriched GO Terms of Interacting Partners?
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