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EXOSC4 and UPF3B
Data Source:
HPRD
(in vitro, in vivo)
EXOSC4
UPF3B
Description
exosome component 4
UPF3B regulator of nonsense mediated mRNA decay
Image
GO Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Intracellular Membrane-bounded Organelle
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Centriolar Satellite
Exon-exon Junction Complex
Molecular Function
3'-5'-exoribonuclease Activity
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
RNA Binding
MRNA Binding
Protein Binding
Structural Constituent Of Nuclear Pore
Biological Process
Maturation Of 5.8S RRNA
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
RRNA Catabolic Process
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
DNA Deamination
Defense Response To Virus
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
MRNA Splicing, Via Spliceosome
RNA Export From Nucleus
MRNA Export From Nucleus
MRNA 3'-end Processing
Positive Regulation Of Translation
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS
Asthma (
31959851
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Interacting Genes
33 interacting genes:
AKR1A1
DIS3
DXO
EEF1A1
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FAHD1
GADD45GIP1
GTF2IRD1
HBS1L
HNRNPD
LNX1
LRRC8D
MPZL1
MTREX
NEK1
PALS2
POLE2
PPARA
PTEN
SDCBP
SKIV2L
SMPD4
TSEN15
UPF1
UPF2
UPF3B
13 interacting genes:
EIF4A3
EIF6
EXOSC4
HBB
MAGOH
MCRS1
RBBP6
RBM8A
SRPK2
TTC19
UPF1
UPF2
XRN1
Entrez ID
54512
65109
HPRD ID
16221
02247
Ensembl ID
ENSG00000178896
ENSG00000125351
Uniprot IDs
Q9NPD3
Q9BZI7
PDB IDs
2NN6
6D6Q
6D6R
6H25
1UW4
2XB2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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