SORBS1 and RTN4IP1

Data Source:
BioGRID (two hybrid)

		SORBS1	RTN4IP1
Description		sorbin and SH3 domain containing 1	reticulon 4 interacting protein 1
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GO Annotations	Cellular Component	Stress Fiber Nucleus Centrosome Cytosol Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Nuclear Matrix Cell-substrate Junction Membrane Raft	Mitochondrion Mitochondrial Outer Membrane
	Molecular Function	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	Protein Binding Zinc Ion Binding Oxidoreductase Activity
	Biological Process	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Nervous System Development Regulation Of Dendrite Development
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)	Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483)
Interacting Genes		27 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL	23 interacting genes: ARFGAP3 CALCOCO2 CBFA2T3 CENPK CTAG1A CTAG1B ERMN EXOC7 GGA2 HDX MARCHF5 PPP1R8 PYM1 RELA RTN4 RTN4R RUNX1T1 SCAF1 SMURF2 SORBS1 WBP11 WWTR1 ZYX
Entrez ID		10580	84816
HPRD ID		05587	18008
Ensembl ID		ENSG00000095637	ENSG00000130347
Uniprot IDs		B4DTX5 Q9BX66	Q8WWV3
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP	2VN8
Enriched GO Terms of Interacting Partners?
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