SORBS1 and INSM1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SORBS1	INSM1
Description		sorbin and SH3 domain containing 1	INSM transcriptional repressor 1
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GO Annotations	Cellular Component	Stress Fiber Nucleus Centrosome Cytosol Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Nuclear Matrix Cell-substrate Junction Membrane Raft	Nucleus Nucleoplasm Transcription Repressor Complex
	Molecular Function	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cyclin Binding Chromatin DNA Binding Histone Deacetylase Binding Metal Ion Binding
	Biological Process	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Phosphorylation Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Type B Pancreatic Cell Development Noradrenergic Neuron Development Cell Cycle Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Regulation Of Cell Cycle Process Neuron Differentiation Positive Regulation Of Cell Migration Endocrine Pancreas Development Norepinephrine Biosynthetic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Transdifferentiation Adrenal Chromaffin Cell Differentiation Sympathetic Ganglion Development Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Smooth Muscle Contraction	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)
Interacting Genes		27 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL	5 interacting genes: CCND1 KDM1A MPP3 SORBS1 TUBB3
Entrez ID		10580	3642
HPRD ID		05587	02480
Ensembl ID		ENSG00000095637	ENSG00000173404
Uniprot IDs		B4DTX5 Q9BX66	Q01101
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP	2LV2 3ZMS
Enriched GO Terms of Interacting Partners?
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