SORBS1 and PAK2

Data Source:
HPRD (in vitro)

		SORBS1	PAK2
Description		sorbin and SH3 domain containing 1	p21 (RAC1) activated kinase 2
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GO Annotations	Cellular Component	Stress Fiber Nucleus Centrosome Cytosol Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Nuclear Matrix Cell-substrate Junction Membrane Raft	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Perinuclear Region Of Cytoplasm Glutamatergic Synapse
	Molecular Function	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Phosphorylation Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Adherens Junction Assembly Interleukin-12-mediated Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Dendritic Spine Development Positive Regulation Of Protein Tyrosine Kinase Activity Bicellular Tight Junction Assembly Cellular Response To Organic Cyclic Compound Protein Localization To Cell-cell Junction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Smooth Muscle Contraction	Nef and signal transduction Generation of second messenger molecules Regulation of PAK-2p34 activity by PS-GAP/RHG10 Regulation of activated PAK-2p34 by proteasome mediated degradation Stimulation of the cell death response by PAK-2p34 FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFA-VEGFR2 Pathway Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Fostamatinib
Diseases
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)	Asthma ( 31959851) Atrial fibrillation ( 29892015) Eosinophil counts ( 32888494 27863252) Glucose homeostasis traits ( 25524916) Lymphocyte counts ( 32888494 27863252) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) White blood cell count ( 32888494 27863252)
Interacting Genes		27 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL	54 interacting genes: ABI1 ABI2 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 H4C6 HCK LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NCK2 NPHP1 PACSIN3 PPM1A RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1
Entrez ID		10580	5062
HPRD ID		05587	05428
Ensembl ID		ENSG00000095637	ENSG00000180370
Uniprot IDs		B4DTX5 Q9BX66	A8K5M4 Q13177
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP	3PCS
Enriched GO Terms of Interacting Partners?
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