DCTN2 and BLOC1S1

Data Source:
BioGRID (two hybrid)

		DCTN2	BLOC1S1
Description		dynactin subunit 2	biogenesis of lysosomal organelles complex 1 subunit 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Exosome	Extracellular Space Mitochondrial Intermembrane Space Mitochondrial Matrix Lysosomal Membrane Cytosol BLOC-1 Complex BORC Complex Axon Cytoplasm
	Molecular Function	Motor Activity Protein Binding Protein Kinase Binding Spectrin Binding Identical Protein Binding	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Spindle Organization Mitotic Metaphase Plate Congression Regulation Of G2/M Transition Of Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Transport Protein Localization To Centrosome Ciliary Basal Body-plasma Membrane Docking	Anterograde Axonal Transport Aerobic Respiration Endosomal Transport Peptidyl-lysine Acetylation Neuron Projection Development Lysosome Localization Melanosome Organization Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Refractive error ( 32231278)
Interacting Genes		35 interacting genes: ABI2 BICD1 BICD2 BLOC1S1 BLOC1S2 BLOC1S6 BORCS6 CALM1 CCDC172 CENPH CEP44 COG3 DISC1 EGFR GADD45A GADD45G GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MAPRE3 MARCKSL1 PAFAH1B1 RABGEF1 RINT1 RPGR SMARCD1 TXLNB USHBP1 ZW10	18 interacting genes: APP BLOC1S2 BLOC1S3 BLOC1S4 BLOC1S5 BLOC1S6 DCTN2 FBXO44 HGS MAGEB4 MTA1 NOTCH1 PBX2 PELP1 PTN SNAPC5 SNAPIN USHBP1
Entrez ID		10540	2647
HPRD ID		09568	03263
Ensembl ID		ENSG00000175203	ENSG00000135441
Uniprot IDs		A0A384MDU9 A8K8J9 B3KTX4 Q13561 V9HW58	P78537
PDB IDs
Enriched GO Terms of Interacting Partners?
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