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CDK4 and BECN1
Data Source:
BioGRID
(fluorescent resonance energy transfer)
CDK4
BECN1
Description
cyclin dependent kinase 4
beclin 1
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytosol
Bicellular Tight Junction
Mediator Complex
Nuclear Membrane
Perinuclear Region Of Cytoplasm
Cyclin D2-CDK4 Complex
Phagophore Assembly Site
Nucleus
Mitochondrion
Endosome
Autophagosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Trans-Golgi Network
Cytosol
Endosome Membrane
Extrinsic Component Of Membrane
Dendrite
Mitochondrial Membrane
Phosphatidylinositol 3-kinase Complex, Class III, Type I
Phosphatidylinositol 3-kinase Complex, Class III, Type II
Phosphatidylinositol 3-kinase Complex, Class III
Phagocytic Vesicle
Molecular Function
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Cyclin Binding
Protein-containing Complex Binding
Protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphatidylinositol 3-kinase Binding
GTPase Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Lens Development In Camera-type Eye
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Signal Transduction
Circadian Rhythm
Positive Regulation Of Cell Population Proliferation
Response To Toxic Substance
Response To Lead Ion
Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Animal Organ Regeneration
Cellular Response To Insulin Stimulus
Response To Testosterone
Regulation Of Multicellular Organism Growth
Response To Drug
Positive Regulation Of Apoptotic Process
Positive Regulation Of Translation
Positive Regulation Of Cell Cycle
Positive Regulation Of Cell Size
Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Lipid Biosynthetic Process
Positive Regulation Of Fibroblast Proliferation
Regulation Of Lipid Catabolic Process
Cell Division
Regulation Of Cell Cycle
Response To Hyperoxia
Adipose Tissue Development
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-4
Cellular Response To Phorbol 13-acetate 12-myristate
Cellular Response To Ionomycin
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Autophagosome Assembly
Autophagy Of Mitochondrion
Mitophagy
Response To Hypoxia
Autophagy
Apoptotic Process
Cellular Defense Response
Cellular Response To Nitrogen Starvation
Lysosome Organization
Mitotic Metaphase Plate Congression
Aging
Negative Regulation Of Cell Population Proliferation
Response To Iron(II) Ion
Response To Lead Ion
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Macroautophagy
Protein Deubiquitination
Regulation Of Cytokinesis
Receptor Catabolic Process
Response To Vitamin E
Cellular Response To Amino Acid Starvation
Cellular Response To Glucose Starvation
Response To Drug
Negative Regulation Of Apoptotic Process
Engulfment Of Apoptotic Cell
Early Endosome To Late Endosome Transport
Late Endosome To Vacuole Transport
Neuron Development
Amyloid-beta Metabolic Process
Regulation Of Catalytic Activity
Cell Division
Defense Response To Virus
Negative Regulation Of Cell Death
Cellular Response To Hydrogen Peroxide
Cellular Response To Aluminum Ion
Cellular Response To Copper Ion
Cellular Response To Epidermal Growth Factor Stimulus
Response To Mitochondrial Depolarisation
Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Negative Regulation Of Autophagosome Assembly
Negative Regulation Of Lysosome Organization
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Autophagosome Assembly
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
SCF(Skp2)-mediated degradation of p27/p21
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Cyclin D associated events in G1
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2
Meiotic recombination
Transcriptional regulation of granulopoiesis
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Macroautophagy
Ub-specific processing proteases
Translation of Replicase and Assembly of the Replication Transcription Complex
Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Purvalanol
Alvocidib
Palbociclib
Ribociclib
Abemaciclib
Fostamatinib
Estradiol
Estradiol acetate
Estradiol benzoate
Estradiol cypionate
Estradiol dienanthate
Estradiol valerate
Diseases
Glioma
Malignant melanoma
Cervical cancer
GWAS
Brain morphology (MOSTest) (
32665545
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Rheumatoid arthritis (
30423114
24390342
)
Type 2 diabetes (age of onset) (
28060188
)
Interacting Genes
134 interacting genes:
AKT1
ANKRD12
ANXA7
APLP1
APP
ARAF
ARID4A
ARNT
ATP5F1B
BAG6
BCL11A
BECN1
BIRC5
BMPR1B
BRCA1
CAMK1
CAPNS1
CCND1
CCND2
CCND3
CCNE1
CD44
CDC37
CDC45
CDC6
CDC7
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CEBPA
CIB1
CNOT7
CNTN2
DAZAP2
DDAH2
DUSP9
EIF4EBP2
EPHA2
ERBB2
FGFR4
FOXM1
FZR1
GLIS2
GRM1
H1-0
H1-1
H1-3
HGF
HIF1A
HMGXB3
HOOK1
HSP90AA1
IFI27
IGF1R
IKZF3
IL15RA
INCA1
KDELR2
LATS2
LNX2
LUC7L2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MAPRE2
MARCKS
MCM2
MDM4
MET
MYC
MYOD1
MZF1
NCOA2
NF2
NOL12
OGDHL
ORC3
OTX2
PDGFRA
PGD
PIAS1
PKM
POLD1
PPP2R1B
PRKAR1A
PSMD10
PTMA
QARS1
RAF1
RASSF1
RB1
RBL1
RBL2
RFC1
RFC4
RPL34
SENP3
SERTAD1
SETDB1
SHOX2
SKP1
SLBP
SMAD2
SMAD3
SNCA
SPOP
STK11
STUB1
TEAD2
TERT
TGFBR1
TK1
TP53
TRMT2A
TSC1
TSPYL2
UBE3A
UBTF
UHRF2
USP17L2
VTA1
WDR33
YBX3
ZBTB16
ZNF101
ZNF219
ZNF335
ZNF655
59 interacting genes:
AKT1
AMBRA1
ARAF
ARNT
ATG3
BCL2
BCL2L1
BCL2L10
BTK
CASP3
CCND2
CDK4
CDK6
CDKN2A
CDKN2B
EPHA2
ERBB2
FGFR4
FRS2
FZR1
GFI1B
GLIS2
GOPC
GRM1
HERC5
ITCH
ITPR1
ITPR3
KAT2A
KDELR2
LATS2
MAP2K3
MAP2K5
MAP2K6
MAPKAPK2
MAPKAPK3
MDM4
MST1
NF2
NXF1
PDGFRA
PGK1
RACK1
RAF1
SENP3
SGF29
SHD
SMAD2
STK11
STYK1
TEAD2
TERT
TRAF2
TSC1
UBC
ULK1
WASHC1
XPO1
YES1
Entrez ID
1019
8678
HPRD ID
00447
05087
Ensembl ID
ENSG00000135446
ENSG00000126581
Uniprot IDs
A0A024RBB6
P11802
A0A024R1X5
B4DQ36
E7EV84
Q14457
W0FFG4
PDB IDs
1LD2
2W96
2W99
2W9F
2W9Z
3G33
5FWK
5FWL
5FWM
5FWP
6P8E
6P8F
6P8G
6P8H
2P1L
2PON
3DVU
4DDP
4MI8
5EFM
5HHE
5VAU
5VAX
5VAY
6DCN
6DCO
6HOI
6HOJ
6HOK
Enriched GO Terms of Interacting Partners
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