HIPK3 and MTMR4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HIPK3	MTMR4
Description		homeodomain interacting protein kinase 3	myotubularin related protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Nuclear Body PML Body	Extracellular Space Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Phosphatidylinositol-3-phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Phosphatase Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
	Biological Process	Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity	Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Autophagy Response To Denervation Involved In Regulation Of Muscle Adaptation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Phosphatidylinositol Dephosphorylation Regulation Of Phosphatidylinositol Dephosphorylation
Pathways			Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Downregulation of TGF-beta receptor signaling
Drugs		Fostamatinib
Diseases
GWAS		Anger ( 24489884) Obese vs. thin ( 30677029) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Cognitive function ( 25644384) Refractive error ( 32231278) Vitamin D levels ( 25208829)
Interacting Genes		37 interacting genes: AR ARRB2 C1QA CREB1 CREBBP DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX	2 interacting genes: HIPK3 NEDD4
Entrez ID		10114	9110
HPRD ID		05111	11945
Ensembl ID		ENSG00000110422	ENSG00000108389
Uniprot IDs		A8KAE4 Q9H422	Q9NYA4
PDB IDs
Enriched GO Terms of Interacting Partners?
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