GJC1 and APOL3

Data Source:
BioGRID (two hybrid)

		GJC1	APOL3
Description		gap junction protein gamma 1	apolipoprotein L3
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Connexin Complex Intercalated Disc Integral Component Of Membrane Synapse	Extracellular Region Cytoplasm Membrane
	Molecular Function	Ion Channel Activity Gap Junction Channel Activity Protein Binding Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling	Lipid Transporter Activity Lipid Binding
	Biological Process	Vasculogenesis Muscle Contraction Cell-cell Junction Assembly Cell-cell Signaling Chemical Synaptic Transmission Visual Perception Gap Junction Assembly Ion Transmembrane Transport Cell Development Cardiac Muscle Tissue Development Atrial Cardiac Muscle Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling	Lipid Transport Inflammatory Response Lipoprotein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Electric Transmission Across Gap Junctions Gap junction assembly
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Estimated glomerular filtration rate ( 31152163) Total intracranial volume ( 31530798)
Interacting Genes		8 interacting genes: APOL3 CNST MEOX2 SLC66A1 TJP1 TJP3 TMEM86A UBQLN4	28 interacting genes: ELOVL4 FATE1 FXYD6-FXYD2 GJA8 GJB1 GJB5 GJC1 GPR152 GPRC5D HAS3 IL7R LHFPL5 LINC00839 LRRC25 MFSD6 NCALD PMP22 RNF19B SGCB SLC16A2 SLC1A5 SLC7A14 STX1A TIMMDC1 TMEM167B TMEM237 TMEM52B TNFRSF10D
Entrez ID		10052	80833
HPRD ID		08819	06264
Ensembl ID		ENSG00000182963	ENSG00000128284
Uniprot IDs		A0A654IDC0 P36383	A0A024R1G6 O95236
PDB IDs		3SHW
Enriched GO Terms of Interacting Partners?
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