DUX4 and CAPN2

Data Source:
BioGRID (pull down)

		DUX4	CAPN2
Description		double homeobox 4	calpain 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Golgi Apparatus Cytosol Nuclear Membrane	Chromatin Nucleus Cytoplasm Mitochondrial Intermembrane Space Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Dendrite Cortical Actin Cytoskeleton Pseudopodium Neuronal Cell Body Membrane Raft Extracellular Exosome Perinuclear Endoplasmic Reticulum
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cysteine-type Peptidase Activity Enzyme Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Female Pregnancy Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Extracellular Matrix Disassembly Regulation Of Interleukin-6 Production Cellular Response To Interferon-beta Response To Hydrogen Peroxide Behavioral Response To Pain Regulation Of Cytoskeleton Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Positive Regulation Of Neuron Death Positive Regulation Of Myoblast Fusion Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways			Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488) Carotenoid levels (alpha-carotene) ( 28002826) Febrile seizures (MMR vaccine-related) ( 25344690) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821) Waist circumference ( 31170924)
Interacting Genes		124 interacting genes: ACTG1 AP2A1 AP3D1 ARF1 ATP5F1C C1QBP CAND1 CAPN2 CAVIN1 CCT6A CLTC COPA CSE1L DDX21 DDX3X DDX5 DES DHX30 DHX36 DHX9 DYNC1H1 EEF2 EFTUD2 ENO1 EP300 EPRS1 FASN FLNA GAPDH GARS1 HMGB1 HNRNPA1L2 HNRNPF HNRNPH1 HNRNPK HNRNPM HNRNPU HSPD1 IARS1 IGF2BP1 IGF2BP3 ILF3 IQGAP1 LDHA MARS1 MCM7 MTHFD1 MYBBP1A MYH10 MYH9 MYL6B NCL NPM1 PABPC1 PABPC4 PARP1 PFAS PKM PPP2R1A PRKDC PRPF8 RAN RPL10 RPL10A RPL12 RPL13 RPL15 RPL17 RPL18 RPL19 RPL21 RPL22 RPL23 RPL23A RPL27A RPL3 RPL30 RPL31 RPL35 RPL36 RPL4 RPL6 RPL7 RPL7A RPL8 RPL9 RPN1 RPS10 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS2 RPS20 RPS24 RPS25 RPS3 RPS3A RPS4X RPS6 RPS7 RPS8 RPS9 SF3B1 SHMT2 SLC25A3 SLC25A5 SLC25A6 SNRNP200 SRSF3 TCP1 TUBB TUBB2A TUBB3 TUBB6 VDAC1 VDAC2 VIM XRCC5 XRCC6 YBX1	23 interacting genes: ATG5 ATXN3 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 DUX4 F2RL1 GAS2 GRK2 KNG1 MAPK1 MAPT MTDH NFKBIA NMT1 PBXIP1 PTPN1 PTPRN TNS1 ZFYVE21
Entrez ID		100288687	824
HPRD ID			00254
Ensembl ID		ENSG00000260596	ENSG00000162909
Uniprot IDs		C3U3A0 Q9UBX2	B4DN77 P17655 Q59EF6
PDB IDs		5Z2S 5Z2T 5Z6Z 5ZFW 5ZFY 5ZFZ 6A8R 6DFY 6E8C 6U81 6U82	1KFU 1KFX 2NQA
Enriched GO Terms of Interacting Partners?
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