CAPN2 and GAS2

Data Source:
HPRD (in vivo)

		CAPN2	GAS2
Description		calpain 2	growth arrest specific 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Mitochondrial Intermembrane Space Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Dendrite Cortical Actin Cytoskeleton Pseudopodium Neuronal Cell Body Membrane Raft Extracellular Exosome Perinuclear Endoplasmic Reticulum	Cytosol Microtubule Actin Filament Membrane
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cysteine-type Peptidase Activity Enzyme Binding Protein-containing Complex Binding	Microtubule Binding Cytoskeletal Anchor Activity Actin Filament Binding
	Biological Process	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Female Pregnancy Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Extracellular Matrix Disassembly Regulation Of Interleukin-6 Production Cellular Response To Interferon-beta Response To Hydrogen Peroxide Behavioral Response To Pain Regulation Of Cytoskeleton Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Positive Regulation Of Neuron Death Positive Regulation Of Myoblast Fusion Positive Regulation Of Phosphatidylcholine Biosynthetic Process	Microtubule Cytoskeleton Organization Initiation Of Primordial Ovarian Follicle Growth Antral Ovarian Follicle Growth Apoptotic Process Cell Cycle Arrest Regulation Of Cell Shape Regulation Of Notch Signaling Pathway Ovulation Actin Crosslink Formation Basement Membrane Organization
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Carotenoid levels (alpha-carotene) ( 28002826) Febrile seizures (MMR vaccine-related) ( 25344690) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821) Waist circumference ( 31170924)	Dialysis-related mortality ( 21546767) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483)
Interacting Genes		23 interacting genes: ATG5 ATXN3 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 DUX4 F2RL1 GAS2 GRK2 KNG1 MAPK1 MAPT MTDH NFKBIA NMT1 PBXIP1 PTPN1 PTPRN TNS1 ZFYVE21	4 interacting genes: ACTA1 APP CAPN2 TBC1D21
Entrez ID		824	2620
HPRD ID		00254	04158
Ensembl ID		ENSG00000162909	ENSG00000148935
Uniprot IDs		B4DN77 P17655 Q59EF6	O43903
PDB IDs		1KFU 1KFX 2NQA
Enriched GO Terms of Interacting Partners?
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