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DUX4 and DYNC1H1
Data Source:
BioGRID
(pull down)
DUX4
DYNC1H1
Description
double homeobox 4
dynein cytoplasmic 1 heavy chain 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Golgi Apparatus
Cytosol
Nuclear Membrane
Extracellular Region
Centrosome
Cytosol
Cytoplasmic Dynein Complex
Microtubule
Cytoplasmic Microtubule
Cell Cortex
Membrane
Dynein Complex
Azurophil Granule Lumen
Extracellular Exosome
Axon Cytoplasm
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Sequence-specific Double-stranded DNA Binding
RNA Binding
Protein Binding
ATP Binding
ATP-dependent Microtubule Motor Activity, Minus-end-directed
Dynein Intermediate Chain Binding
Dynein Light Intermediate Chain Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Multicellular Organism Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of G0 To G1 Transition
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Microtubule-based Movement
Mitotic Spindle Organization
Nuclear Migration
Retrograde Axonal Transport
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Cytoplasmic Microtubule Organization
Positive Regulation Of Intracellular Transport
P-body Assembly
Stress Granule Assembly
Neutrophil Degranulation
Establishment Of Spindle Localization
Cell Division
Regulation Of Mitotic Spindle Organization
Minus-end-directed Vesicle Transport Along Microtubule
Regulation Of Metaphase Plate Congression
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Spindle Assembly
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Neutrophil degranulation
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2
HCMV Early Events
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
Distal hereditary motor neuropathies (dHMN)
GWAS
Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) (
30940143
)
Interacting Genes
124 interacting genes:
ACTG1
AP2A1
AP3D1
ARF1
ATP5F1C
C1QBP
CAND1
CAPN2
CAVIN1
CCT6A
CLTC
COPA
CSE1L
DDX21
DDX3X
DDX5
DES
DHX30
DHX36
DHX9
DYNC1H1
EEF2
EFTUD2
ENO1
EP300
EPRS1
FASN
FLNA
GAPDH
GARS1
HMGB1
HNRNPA1L2
HNRNPF
HNRNPH1
HNRNPK
HNRNPM
HNRNPU
HSPD1
IARS1
IGF2BP1
IGF2BP3
ILF3
IQGAP1
LDHA
MARS1
MCM7
MTHFD1
MYBBP1A
MYH10
MYH9
MYL6B
NCL
NPM1
PABPC1
PABPC4
PARP1
PFAS
PKM
PPP2R1A
PRKDC
PRPF8
RAN
RPL10
RPL10A
RPL12
RPL13
RPL15
RPL17
RPL18
RPL19
RPL21
RPL22
RPL23
RPL23A
RPL27A
RPL3
RPL30
RPL31
RPL35
RPL36
RPL4
RPL6
RPL7
RPL7A
RPL8
RPL9
RPN1
RPS10
RPS13
RPS14
RPS15
RPS15A
RPS16
RPS17
RPS18
RPS2
RPS20
RPS24
RPS25
RPS3
RPS3A
RPS4X
RPS6
RPS7
RPS8
RPS9
SF3B1
SHMT2
SLC25A3
SLC25A5
SLC25A6
SNRNP200
SRSF3
TCP1
TUBB
TUBB2A
TUBB3
TUBB6
VDAC1
VDAC2
VIM
XRCC5
XRCC6
YBX1
19 interacting genes:
BRCA1
COX20
DISC1
DUX4
DYNLL1
EGFR
KATNA1
KATNB1
LINC01554
MTNR1B
NDEL1
PRKCD
RHBDD2
SMAD2
SUMO2
TENT5A
TNIK
YWHAG
YWHAQ
Entrez ID
100288687
1778
HPRD ID
02524
Ensembl ID
ENSG00000260596
ENSG00000197102
Uniprot IDs
C3U3A0
Q9UBX2
Q14204
PDB IDs
5Z2S
5Z2T
5Z6Z
5ZFW
5ZFY
5ZFZ
6A8R
6DFY
6E8C
6U81
6U82
2BOR
2BOT
5NUG
5OWO
6F1T
6F1U
6F1V
6F1Y
6F38
6F3A
Enriched GO Terms of Interacting Partners
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