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CDC42 and LRP2
Number of citations of the paper that reports this interaction (PubMedID
18426980
)
45
Data Source:
BioGRID
(pull down)
CDC42
LRP2
Description
cell division cycle 42
LDL receptor related protein 2
Image
GO Annotations
Cellular Component
Golgi Membrane
Storage Vacuole
Cell
Cytoplasm
Endoplasmic Reticulum Membrane
Centrosome
Cytosol
Cytoskeleton
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Cortex
Membrane
Golgi Transport Complex
Secretory Granule
Filopodium
Midbody
Leading Edge Membrane
Cytoplasmic Vesicle
Protein-containing Complex
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Intracellular Membrane-bounded Organelle
Apical Part Of Cell
Phagocytic Vesicle
Spindle Midzone
Extracellular Exosome
Mitotic Spindle
Schaffer Collateral - CA1 Synapse
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Clathrin-coated Pit
External Side Of Plasma Membrane
Integral Component Of Membrane
Apical Plasma Membrane
Endocytic Vesicle
Axon
Dendrite
Clathrin-coated Vesicle Membrane
Brush Border Membrane
Endosome Lumen
Receptor Complex
Extracellular Exosome
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
Protein Kinase Binding
GTP-dependent Protein Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Thioesterase Binding
GBD Domain Binding
Apolipoprotein A-I Receptor Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Calcium Ion Binding
Protein Binding
Drug Binding
SH3 Domain Binding
Insulin-like Growth Factor I Binding
Chaperone Binding
Biological Process
Sprouting Angiogenesis
Cardiac Conduction System Development
Endocytosis
Phagocytosis, Engulfment
Actin Filament Organization
Golgi Organization
Regulation Of Mitotic Nuclear Division
Nuclear Migration
Establishment Or Maintenance Of Cell Polarity
Integrin-mediated Signaling Pathway
Rho Protein Signal Transduction
Blood Coagulation
Regulation Of Cell Shape
Regulation Of Lamellipodium Assembly
Positive Regulation Of Lamellipodium Assembly
Cell Migration
Protein Ubiquitination
Substantia Nigra Development
Cell Projection Assembly
Actin Cytoskeleton Organization
Macrophage Differentiation
Positive Regulation Of Cell Growth
Cortical Cytoskeleton Organization
Positive Regulation Of Pseudopodium Assembly
T Cell Costimulation
Negative Regulation Of Protein Complex Assembly
Positive Regulation Of Cytokinesis
Cdc42 Protein Signal Transduction
Regulation Of Actin Cytoskeleton Organization
Cell Junction Assembly
Adherens Junction Organization
Cellular Protein Localization
Interleukin-12-mediated Signaling Pathway
Dendritic Cell Migration
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neuropilin Signaling Pathway
Viral RNA Genome Replication
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Protein Binding
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Establishment Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of DNA Replication
Positive Regulation Of JNK Cascade
Filopodium Assembly
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Positive Regulation Of Pinocytosis
Neuron Fate Determination
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Muscle Cell Differentiation
Regulation Of Filopodium Assembly
Positive Regulation Of Filopodium Assembly
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Establishment Of Golgi Localization
Positive Regulation Of Synapse Structural Plasticity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Heart Contraction
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Submandibular Salivary Gland Formation
Dendritic Spine Morphogenesis
Cellular Response To Interferon-gamma
Organelle Transport Along Microtubule
Actin Filament Branching
Positive Regulation Of Intracellular Protein Transport
Regulation Of Modification Of Postsynaptic Structure
Modification Of Synaptic Structure
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Actin Cytoskeleton Reorganization
Retinoid Metabolic Process
Neural Tube Closure
Secondary Heart Field Specification
Outflow Tract Septum Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Ventricular Septum Development
Lipid Metabolic Process
Endocytosis
Receptor-mediated Endocytosis
Sensory Perception Of Sound
Cell Proliferation
Male Gonad Development
Protein Transport
Metal Ion Transport
Negative Regulation Of BMP Signaling Pathway
Forebrain Development
Aorta Development
Vitamin D Metabolic Process
Negative Regulation Of Apoptotic Process
Response To Leptin
Transcytosis
Positive Regulation Of Neurogenesis
Positive Regulation Of Protein Kinase B Signaling
Vagina Development
Coronary Artery Morphogenesis
Membrane Organization
Pulmonary Artery Morphogenesis
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Cellular Response To Growth Factor Stimulus
Amyloid-beta Clearance
Neuron Projection Arborization
Folate Import Across Plasma Membrane
Positive Regulation Of Lysosomal Protein Catabolic Process
Pathways
GPVI-mediated activation cascade
EGFR downregulation
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
EPHB-mediated forward signaling
DCC mediated attractive signaling
Inactivation of CDC42 and RAC1
VEGFA-VEGFR2 Pathway
Myogenesis
Myogenesis
RHO GTPases activate KTN1
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
G beta:gamma signalling through CDC42
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
Vitamin D (calciferol) metabolism
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Retinoid metabolism and transport
Drugs
Aminophosphonic Acid-Guanylate Ester
Guanosine-5'-Diphosphate
Urokinase
Insulin Human
Insulin Pork
Gentamicin
Diseases
Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS
Colorectal cancer (
25990418
)
Daytime sleep phenotypes (
27126917
)
Extremely high intelligence (
29520040
)
Gestational age at birth (maternal effect) (
28877031
)
Immune response to smallpox vaccine (IL-6) (
22610502
)
Metabolite levels (
23823483
)
Uterine fibroids (
31249589
30194396
31649266
)
Anorexia nervosa (
21079607
)
Blood pressure (smoking interaction) (
25189868
)
Chronic kidney disease (
29124443
)
Creatinine levels (
29124443
29403010
)
Estimated glomerular filtration rate (
31152163
31015462
31451708
29779033
29124443
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Glomerular filtration rate (
27588450
29403010
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
Hyperuricemia (
29124443
)
Macular thickness (
30535121
)
Optic disc size (
31809533
)
Proteinuria (
30476138
)
Proteinuria (mild) (
30476138
)
Proteinuria (moderate to severe) (
30476138
)
Relapse in multiple sclerosis (
28739605
)
Serum creatinine levels (
29779033
)
Serum uric acid levels (
30993211
29124443
29403010
)
Urate levels (
31578528
20139978
)
Interacting Genes
150 interacting genes:
A2M
ACTR3
AGAP1
AGAP2
AHSG
ANXA2
APOH
ARHGAP1
ARHGAP10
ARHGAP17
ARHGAP26
ARHGAP27
ARHGAP31
ARHGAP32
ARHGAP35
ARHGAP44
ARHGDIA
ARHGDIB
ARHGDIG
ARHGEF11
ARHGEF25
ARHGEF6
ARHGEF7
ARRB1
ARRB2
BAIAP2
BCR
BIRC2
BNIP2
CASP3
CASP7
CBLL1
CDC42BPA
CDC42BPB
CDC42BPG
CDC42EP1
CDC42EP2
CDC42EP3
CDC42EP4
CDC42EP5
CDC42SE1
CDH1
CFHR4
CPN1
CSN2
CSPG4
DEF6
DIAPH2
DIAPH3
DOCK7
DOCK8
DOCK9
EEF1G
EIF2AK2
EPHA2
ERCC3
ERG28
ERRFI1
ETFA
FGD1
FGD3
FLNA
FMN2
FMNL2
FNBP1
GDI1
GRB2
HERC2
IQGAP1
IQGAP2
ITSN1
KAT5
KIAA2026
KTN1
LCK
LGALS1
LRIF1
LRP2
MAP2K3
MAP3K10
MAP3K11
MAP3K4
MAP4
MARK4
MCF2
MCF2L
MCM3AP
METAP2
MT-CO1
MUC12
MYO6
MYO9A
NCF2
NEK6
OCRL
OPHN1
PAK1
PAK2
PAK3
PAK4
PAK5
PAK6
PARD3
PARD6A
PARD6B
PARD6G
PCM1
PDE6D
PGGT1B
PIK3R1
PLD1
PLEKHG2
PRKCA
PRKCG
PRKCI
PRKCZ
RAC2
RAP1GDS1
RHOJ
RIOK3
RPL22
RPL23
RPS6KB1
S100A9
SH3D19
SRGAP1
SSX2IP
ST13
STAU1
SYNE1
TBC1D3F
TNK2
TP53
TRAF2
TRIP10
UBC
UBR1
UNC119
USP6
VAV1
VRK2
WAS
WASF1
WASF2
WASL
WIPF1
XIAP
ZNF175
ZNF234
ZNF420
51 interacting genes:
ALB
ANAPC10
ANKRA2
ANKS1B
APBA2
APBB1
APOB
APOE
APOH
APP
ATN1
CDC42
CLU
CUBN
DAB1
DAB2
DLG1
DLG2
DLG3
DLG4
GC
GIPC1
GPRASP1
INS
ITGB1BP1
LCN2
LDLRAP1
LPA
LPL
LRP2BP
LRPAP1
MAGI1
MAPK8IP1
MAPK8IP2
MDK
NOS1AP
PIP5K1C
PLAU
RAC1
RBP1
RHOA
SCGB1A1
SCN3A
SERPINE1
SLC9A3
SNX17
SYNJ2BP
TG
THBS1
TLN1
TTR
Entrez ID
998
4036
HPRD ID
00309
02509
Ensembl ID
ENSG00000070831
ENSG00000081479
Uniprot IDs
A0A024RAE6
P60953
P98164
Q7Z5C0
Q7Z5C1
PDB IDs
1A4R
1AJE
1AM4
1AN0
1CEE
1CF4
1DOA
1E0A
1EES
1GRN
1GZS
1KI1
1KZ7
1KZG
1NF3
2ASE
2DFK
2KB0
2NGR
2ODB
2QRZ
2WM9
2WMN
2WMO
3GCG
3QBV
3VHL
4DID
4ITR
4JS0
4YC7
4YDH
5CJP
5FI1
5HZK
5UPK
5UPL
6AJ4
6AJL
2M0P
Enriched GO Terms of Interacting Partners
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