LRP2 and SCN3A

Number of citations of the paper that reports this interaction (PubMedID 10827173)
122

Data Source:
BioGRID (two hybrid)

		LRP2	SCN3A
Description		LDL receptor related protein 2	sodium voltage-gated channel alpha subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Vesicle Membrane Brush Border Membrane Endosome Lumen Receptor Complex Extracellular Exosome	Voltage-gated Sodium Channel Complex Cytoplasm Plasma Membrane Axon
	Molecular Function	Calcium Ion Binding Protein Binding Drug Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Chaperone Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Cation Channel Activity
	Biological Process	Retinoid Metabolic Process Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Sensory Perception Of Sound Cell Proliferation Male Gonad Development Protein Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Positive Regulation Of Protein Kinase B Signaling Vagina Development Coronary Artery Morphogenesis Membrane Organization Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Folate Import Across Plasma Membrane Positive Regulation Of Lysosomal Protein Catabolic Process	Sodium Ion Transport Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways		Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Urokinase Insulin Human Insulin Pork Gentamicin	Phenytoin Valproic Acid Zonisamide Tetrodotoxin Brivaracetam Lacosamide
Diseases		Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS		Anorexia nervosa ( 21079607) Blood pressure (smoking interaction) ( 25189868) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 29779033 29124443 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Hyperuricemia ( 29124443) Macular thickness ( 30535121) Optic disc size ( 31809533) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Relapse in multiple sclerosis ( 28739605) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29124443 29403010) Urate levels ( 31578528 20139978)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Epilepsy ( 30531953) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Metabolite levels ( 23823483) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Parkinson's disease ( 28892059) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		51 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR	5 interacting genes: CNTN1 LRP1 LRP2 LRP8 PRKCG
Entrez ID		4036	6328
HPRD ID		02509	01671
Ensembl ID		ENSG00000081479	ENSG00000153253
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	A0A590UJH3 Q9C007 Q9NY46
PDB IDs		2M0P
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?