NCOR2 and RARG

Number of citations of the paper that reports this interaction (PubMedID 15604093)
54

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		NCOR2	RARG
Description		nuclear receptor corepressor 2	retinoic acid receptor gamma
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcriptional Repressor Complex	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Integral Component Of Membrane RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Nuclear Hormone Receptor Binding Glucocorticoid Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein-containing Complex Binding Retinoid X Receptor Binding Protein N-terminus Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Retinoid X Receptor Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lactation Response To Organonitrogen Compound Regulation Of Cellular Ketone Metabolic Process Regulation Of Lipid Metabolic Process Response To Estradiol Estrous Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Glandular Epithelial Cell Development Growth Plate Cartilage Chondrocyte Growth Transcription Initiation From RNA Polymerase II Promoter Multicellular Organism Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Size Hormone-mediated Signaling Pathway Anterior/posterior Pattern Specification Cell Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Response To Lipid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Steroid Hormone Mediated Signaling Pathway Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Organ Development Gland Development Canonical Wnt Signaling Pathway Face Development Bone Morphogenesis Epithelium Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Harderian Gland Development Cellular Response To Retinoic Acid Cellular Response To Leukemia Inhibitory Factor
Pathways		PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate SR11254 4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid CD564 Dodecyl-Alpha-D-Maltoside BMS184394 R667 LGD-1550 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Clubfoot ( 24667120) Cocaine dependence ( 23958962) Cognitive performance ( 19734545) Diastolic blood pressure ( 30224653) Height ( 31562340) Lung function (FEV1) ( 30061609) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Anthracycline-induced cardiotoxicity in childhood cancer ( 26237429) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
Interacting Genes		88 interacting genes: AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CBFA2T2 CDK2 CEBPB CEP63 CHUK CIR1 CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 H4C1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HNF4A INPP5K IRF5 JUN KLF5 MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PIN1 PML POU2F1 PPARA PPARD PPARG RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SIN3A SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBE2I VDR YWHAE ZBTB16 ZBTB7A	32 interacting genes: ACY3 ARID1A HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 NCOA1 NCOA3 NCOR1 NCOR2 NEK9 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 PRIM1 PSMC5 RHPN2 RXRA RXRB RXRG S100A3 SMAD3 SMARCD3 SPHK1 TNIP1 ZNF576
Entrez ID		9612	5916
HPRD ID		02910	01573
Ensembl ID		ENSG00000196498	ENSG00000172819
Uniprot IDs		C9J0Q5 C9JE98 Q9Y618	A8K3H3 B7Z4B4 F1D8P1 P13631
PDB IDs		1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 2RT5 3R29 3R2A 4A69 4OAR 5X8Q 5X8X 5ZOO 5ZOP 6A22 6IVX	1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD 5M24 6FX0
Enriched GO Terms of Interacting Partners?
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