MVP and EPHX2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MVP	EPHX2
Description		major vault protein	epoxide hydrolase 2
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Pore Cytoplasm Cytosol Cytoskeleton Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen	Peroxisome Peroxisomal Matrix Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding	Magnesium Ion Binding Epoxide Hydrolase Activity Toxic Substance Binding Phosphatase Activity 10-hydroxy-9-(phosphonooxy)octadecanoate Phosphatase Activity Lipid Phosphatase Activity Protein Homodimerization Activity
	Biological Process	Protein Transport Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway Neutrophil Degranulation MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity	Protein Targeting To Peroxisome Response To Toxic Substance Positive Regulation Of Gene Expression Dephosphorylation Epoxygenase P450 Pathway Cholesterol Homeostasis Long-chain Fatty Acid Biosynthetic Process Stilbene Catabolic Process Phospholipid Dephosphorylation Regulation Of Cholesterol Metabolic Process Epoxide Metabolic Process
Pathways		Neutrophil degranulation	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Biosynthesis of maresins Peroxisomal protein import Peroxisomal protein import
Drugs			N-Cyclohexyl-N'-(4-Iodophenyl)Urea N-Cyclohexyl-N'-Decylurea N-Cyclohexyl-N'-(Propyl)Phenyl Urea N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE 4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID Ebselen
Diseases
GWAS			anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Crohn's disease ( 26192919) Dental caries ( 23259602) Inflammatory bowel disease ( 26192919) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Schizophrenia ( 25056061 29483656) Smoking behaviour (cigarettes smoked per day) ( 31089300) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		58 interacting genes: ADAMTSL4 BANP C1orf94 CALCOCO2 CAMK2B CKAP4 DISC1 DLX2 EPHX2 ESR1 GIT2 GOLGA2 HP IHO1 KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MRTFA MT-CYB NNT NOTCH2NLA PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF111 SAXO1 SERTAD1 SKIL SLC2A4 STN1 TCF4 TENT5C TFCP2 TLE5 TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 TSPOAP1 UBC VAC14 ZBTB32 ZMIZ2	5 interacting genes: MTDH MVP NIPSNAP3A PEX5 TERF1
Entrez ID		9961	2053
HPRD ID		05475	00582
Ensembl ID		ENSG00000013364	ENSG00000120915
Uniprot IDs		Q14764 X5D2M8 X5D7K9 X5DNU0	P34913
PDB IDs		1Y7X	1S8O 1VJ5 1ZD2 1ZD3 1ZD4 1ZD5 3ANS 3ANT 3I1Y 3I28 3KOO 3OTQ 3PDC 3WK4 3WK5 3WK6 3WK7 3WK8 3WK9 3WKA 3WKB 3WKC 3WKD 3WKE 4C4X 4C4Y 4C4Z 4HAI 4J03 4JNC 4OCZ 4OD0 4X6X 4X6Y 4Y2J 4Y2P 4Y2Q 4Y2R 4Y2S 4Y2T 4Y2U 4Y2V 4Y2X 4Y2Y 5AHX 5AI0 5AI4 5AI5 5AI6 5AI8 5AI9 5AIA 5AIB 5AIC 5AK3 5AK4 5AK5 5AK6 5AKE 5AKG 5AKH 5AKI 5AKJ 5AKK 5AKL 5AKX 5AKY 5AKZ 5ALD 5ALE 5ALF 5ALG 5ALH 5ALI 5ALJ 5ALK 5ALL 5ALM 5ALN 5ALO 5ALP 5ALQ 5ALR 5ALS 5ALT 5ALU 5ALV 5ALW 5ALX 5ALY 5ALZ 5AM0 5AM1 5AM2 5AM3 5AM4 5AM5 5FP0 5MWA 6AUM 6I5E 6I5G
Enriched GO Terms of Interacting Partners?
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