CDC6 and AKAP8L

Number of citations of the paper that reports this interaction (PubMedID 12538639)
23

Data Source:
HPRD (in vivo)

		CDC6	AKAP8L
Description		cell division cycle 6	A-kinase anchoring protein 8 like
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Spindle Midzone	Chromatin Nucleus Cytoplasm Nuclear Matrix PML Body Nuclear Speck Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding Kinase Binding	DNA Binding RNA Binding Protein Binding Lamin Binding DEAD/H-box RNA Helicase Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding Metal Ion Binding
	Biological Process	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin	MRNA Processing Mitotic Chromosome Condensation RNA Splicing Regulation Of MRNA Export From Nucleus Viral Process Positive Regulation Of Histone Deacetylation Regulation Of Histone Phosphorylation Cell Cycle G2/M Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Nuclear Envelope Disassembly
Pathways		Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription
Drugs
Diseases
GWAS		Asthma ( 31619474)
Interacting Genes		38 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CCNF CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBE2K UBR1	17 interacting genes: ACTN2 AP1M1 ASF1B BEX3 C19orf57 CDC6 DHX9 EMD EPHX3 ICAM4 IL18R1 LBR OR7A17 PRKACA PRPF40A RASAL3 TMPO
Entrez ID		990	26993
HPRD ID		04022	10641
Ensembl ID		ENSG00000094804	ENSG00000011243
Uniprot IDs		A0A024R1S2 Q99741	Q9ULX6
PDB IDs		2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?
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