AKAP8L and CDC6

Number of citations of the paper that reports this interaction (PubMedID 12538639)
23

Data Source:
HPRD (in vivo)

		AKAP8L	CDC6
Description		A-kinase anchoring protein 8 like	cell division cycle 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Nuclear Matrix PML Body Nuclear Speck Ribonucleoprotein Complex	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Spindle Midzone
	Molecular Function	DNA Binding RNA Binding Protein Binding Lamin Binding DEAD/H-box RNA Helicase Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding Metal Ion Binding	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding Kinase Binding
	Biological Process	MRNA Processing Mitotic Chromosome Condensation RNA Splicing Regulation Of MRNA Export From Nucleus Viral Process Positive Regulation Of Histone Deacetylation Regulation Of Histone Phosphorylation Cell Cycle G2/M Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Nuclear Envelope Disassembly	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin
Pathways			Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription
Drugs
Diseases
GWAS			Asthma ( 31619474)
Interacting Genes		17 interacting genes: ACTN2 AP1M1 ASF1B BEX3 C19orf57 CDC6 DHX9 EMD EPHX3 ICAM4 IL18R1 LBR OR7A17 PRKACA PRPF40A RASAL3 TMPO	38 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CCNF CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBE2K UBR1
Entrez ID		26993	990
HPRD ID		10641	04022
Ensembl ID		ENSG00000011243	ENSG00000094804
Uniprot IDs		Q9ULX6	A0A024R1S2 Q99741
PDB IDs			2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?
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