ARHGEF11 and SLC1A6

Number of citations of the paper that reports this interaction (PubMedID 11242047)
61

Data Source:
HPRD (in vivo, in vitro)

		ARHGEF11	SLC1A6
Description		Rho guanine nucleotide exchange factor 11	solute carrier family 1 member 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Intermediate Filament Cytoskeleton Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	G Protein-coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	High-affinity Glutamate Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Striated Muscle Contraction G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction	Neurotransmitter Uptake Ion Transport Chemical Synaptic Transmission Glutamate Secretion Aspartate Transmembrane Transport L-glutamate Transmembrane Transport Regulation Of Membrane Potential L-aspartate Transmembrane Transport L-glutamate Import Across Plasma Membrane
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse	Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides
Drugs			Glutamic Acid
Diseases
GWAS		Chin dimples ( 27182965) Heel bone mineral density ( 30598549) Height ( 31562340)	Familial squamous cell lung carcinoma ( 29924316)
Interacting Genes		15 interacting genes: ABCA1 CDC42 GNA12 GNA13 LPAR1 LPAR2 MAP1A MAP1B PLXNB1 PLXNB2 PLXNB3 PTPRF RHOA RPS6KA1 SLC1A6	2 interacting genes: ARHGEF11 ARIH2
Entrez ID		9826	6511
HPRD ID		09302	09005
Ensembl ID		ENSG00000132694	ENSG00000105143
Uniprot IDs		O15085	B7Z7Q5 P48664
PDB IDs		1HTJ 1XCG 2DLS 3KZ1 3T06 5E6P 5JHG 5JHH 5TYT
Enriched GO Terms of Interacting Partners?
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