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ARHGEF11

Description Rho guanine nucleotide exchange factor 11
Image
GO Annotations Cellular Component
  • Cytoplasm
  • Cytosol
  • Membrane
Molecular Function
  • G Protein-coupled Receptor Binding
  • Rho Guanyl-nucleotide Exchange Factor Activity
  • GTPase Activator Activity
  • Protein Binding
Biological Process
  • Regulation Of Cell Growth
  • Striated Muscle Contraction
  • G Protein-coupled Receptor Signaling Pathway
  • Rho Protein Signal Transduction
  • Establishment Of Cell Polarity
  • Actin Cytoskeleton Organization
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of GTPase Activity
  • Positive Regulation Of Transcription, DNA-templated
  • Regulation Of Small GTPase Mediated Signal Transduction
Pathways
  • NRAGE signals death through JNK
  • Rho GTPase cycle
  • G alpha (12/13) signalling events
  • Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
  • Chin dimples ( 27182965)
  • Heel bone mineral density ( 30598549)
  • Height ( 31562340)
Interacting Genes 15 interacting genes: ABCA1 CDC42 GNA12 GNA13 LPAR1 LPAR2 MAP1A MAP1B PLXNB1 PLXNB2 PLXNB3 PTPRF RHOA RPS6KA1 SLC1A6
Entrez ID 9826
HPRD ID 09302
Ensembl ID ENSG00000132694
Uniprot IDs O15085
PDB IDs 1HTJ 1XCG 2DLS 3KZ1 3T06 5E6P 5JHG 5JHH 5TYT
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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