DAZAP2 and OTULIN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DAZAP2	OTULIN
Description		DAZ associated protein 2	OTU deubiquitinase with linear linkage specificity
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Nuclear Speck Protein-containing Complex	Cytoplasm Cytosol LUBAC Complex
	Molecular Function	Protein Binding Receptor Tyrosine Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity WW Domain Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Positive Regulation Of Protein Serine/threonine Kinase Activity	Sprouting Angiogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination
Pathways			Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS			Asthma ( 31619474) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058)
Interacting Genes		91 interacting genes: AATF ARID5A ATXN1 ATXN1L BAG3 BATF2 C1orf94 CALCOCO2 CCDC120 CDK4 CEP70 CLASRP COL4A2 COL4A5 CXCL12 DAB1 DAZ1 DAZL DCUN1D1 EPN1 EXD3 FAM168A FBN3 GPSM1 HGS HIP1 INCA1 KRTAP19-5 KRTAP8-1 LASP1 LMO2 MAGED1 MED31 NDUFA5 NEDD4 NEDD4L NOC4L NOTCH1 OPTN OTULIN PEF1 PLEKHB2 PLSCR1 POGZ POLI PRR20A RABGEF1 RBFOX1 RBFOX2 RBM11 RBPMS RHOXF2 RNF115 RNF208 ROR2 RPS27A SEPTIN2 SMAP2 SMURF2 SOX6 SQSTM1 STAM2 STAT6 TAX1BP1 TCF7L2 TENT5B TENT5C TEX37 TLE1 TNIP3 TOLLIP UBA52 UBAC1 UBASH3A UBASH3B UBB UBC UBE2D4 UBE2E2 UBE3A UBQLN4 USP5 VHLL VPS37C WDR73 WWP1 ZC3H10 ZFAND2B ZFYVE9 ZNF34 ZNF581	6 interacting genes: BCL10 DAZAP2 DVL2 FAM168A SPATA2 VCP
Entrez ID		9802	90268
HPRD ID		08463	14266
Ensembl ID		ENSG00000183283	ENSG00000154124
Uniprot IDs		A0A024R110 Q15038	Q96BN8
PDB IDs			3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK
Enriched GO Terms of Interacting Partners?
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