OTULIN and SPATA2

Number of citations of the paper that reports this interaction (PubMedID 27545878)
30

Data Source:
BioGRID (unspecified method)

		OTULIN	SPATA2
Description		OTU deubiquitinase with linear linkage specificity	spermatogenesis associated 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol LUBAC Complex	Fibrillar Center Nucleoplasm Cytoplasm
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity	Molecular_function Protein Binding
	Biological Process	Sprouting Angiogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination	Multicellular Organism Development Spermatogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Regulation Of Inflammatory Response Regulation Of Necroptotic Process Protein K63-linked Deubiquitination Protein Linear Deubiquitination
Pathways		Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058)	Coronary artery disease ( 29212778) Gut microbiota (beta diversity) ( 27723756) Psoriasis ( 20953189 25574825 18364390)
Interacting Genes		6 interacting genes: BCL10 DAZAP2 DVL2 FAM168A SPATA2 VCP	11 interacting genes: APP CEP72 DUT GOLGA2 LZTS2 MAD1L1 OTULIN PTPN6 RNF31 TRAF2 TRIM27
Entrez ID		90268	9825
HPRD ID		14266	09636
Ensembl ID		ENSG00000154124	ENSG00000158480
Uniprot IDs		Q96BN8	A8K0S9 B4DID4 Q9UM82
PDB IDs		3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK	5LJM 5LJN
Enriched GO Terms of Interacting Partners?
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