RAPGEF5 and MRAS

Number of citations of the paper that reports this interaction (PubMedID 10934204)
39

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		RAPGEF5	MRAS
Description		Rap guanine nucleotide exchange factor 5	muscle RAS oncogene homolog
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body	Plasma Membrane
	Molecular Function	Ras Guanyl-nucleotide Exchange Factor Activity Rap Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Nervous System Development	Ras Protein Signal Transduction Multicellular Organism Development Muscle Organ Development Actin Cytoskeleton Organization Cellular Response To Leukemia Inhibitory Factor
Pathways
Drugs
Diseases
GWAS		Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Glaucoma ( 30104761) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Chronotype ( 30696823) Coronary artery disease ( 29212778 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 19198612 21378990) Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		7 interacting genes: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1	12 interacting genes: AFDN BRAF ELOC LZTR1 PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 RHOU
Entrez ID		9771	22808
HPRD ID		15208	06662
Ensembl ID		ENSG00000136237	ENSG00000158186
Uniprot IDs		A8MQ07 Q5JPD2 Q92565	O14807 Q6FGP0 Q8WVM9
PDB IDs		1WGY
Enriched GO Terms of Interacting Partners?
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