KMT2B and RPP14

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		KMT2B	RPP14
Description		lysine methyltransferase 2B	ribonuclease P/MRP subunit p14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nucleoplasm Nucleolus Multimeric Ribonuclease P Complex
	Molecular Function	DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Unmethylated CpG Binding	Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	Ovarian Follicle Development Memory Oocyte Differentiation Gene Silencing Ovulation Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Chromatin-mediated Maintenance Of Transcription Histone H3-K4 Methylation Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation	TRNA 5'-leader Removal RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Height ( 28552196) Rheumatoid arthritis (ACPA-positive) ( 24532676) Total cholesterol levels ( 30275531)
Interacting Genes		25 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TSC22D1 ZNF512B	19 interacting genes: A2M ATP5F1B CAPZB DOCK7 EXOSC8 IGSF21 KMT2B LIMD1 MSH2 NOVA1 PKM POP4 POP5 PSME1 RPP25 RPP30 RPP38 RPP40 WIZ
Entrez ID		9757	11102
HPRD ID		06017	18001
Ensembl ID		ENSG00000272333	ENSG00000163684
Uniprot IDs		Q9UMN6	O95059
PDB IDs		3UVM 4ERZ 4PZI	6AHR 6AHU
Enriched GO Terms of Interacting Partners?
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