SETD1A and DPY30

Number of citations of the paper that reports this interaction (PubMedID 23870121)
65

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SETD1A	DPY30
Description		SET domain containing 1A, histone lysine methyltransferase	dpy-30 histone methyltransferase complex regulatory subunit
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex
	Molecular Function	RNA Binding Protein Binding Beta-catenin Binding Transcription Factor Binding Histone Methyltransferase Activity (H3-K4 Specific)	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Chromatin Organization	Endosomal Transport Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Mean corpuscular hemoglobin ( 27863252) Multiple sclerosis ( 31604244) Parkinson's disease ( 31660654) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		6 interacting genes: BCKDK DPY30 EP300 H3C1 H3C14 LBP	14 interacting genes: ARFGEF1 ASH2L CHMP2B DYDC1 GTF2I H3-4 KMT2C OTX1 PRPF3 PRRC2B PSMD14 SETD1A TMCC2 UBC
Entrez ID		9739	84661
HPRD ID		13795	17434
Ensembl ID		ENSG00000099381	ENSG00000162961
Uniprot IDs		O15047	B4DIS3 Q9C005
PDB IDs		3S8S 3UVN 4EWR	3G36 4RIQ 4RT4 4RTA 6E2H
Enriched GO Terms of Interacting Partners?
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