SETD1A and BCKDK

		SETD1A	BCKDK
Description		SET domain containing 1A, histone lysine methyltransferase	branched chain keto acid dehydrogenase kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex
	Molecular Function	RNA Binding Protein Binding Beta-catenin Binding Transcription Factor Binding Histone Methyltransferase Activity (H3-K4 Specific)	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity
	Biological Process	Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Chromatin Organization	Protein Phosphorylation Cellular Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Phosphorylation Glucose Homeostasis Negative Regulation Of Pyruvate Dehydrogenase Activity
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Branched-chain amino acid catabolism
Drugs			Adenosine 5'-[Î³-thio]triphosphate
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Mean corpuscular hemoglobin ( 27863252) Multiple sclerosis ( 31604244) Parkinson's disease ( 31660654) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009)
Interacting Genes		6 interacting genes: BCKDK DPY30 EP300 H3C1 H3C14 LBP	17 interacting genes: APP BCKDHB CDIPT EIF3C EPS8 FBXO7 FOXO1 GUCA1A LSM8 NR5A2 PCDHB9 QPRT SETD1A STAT3 TAOK2 TRAF4 ZNF267
Entrez ID		9739	10295
HPRD ID		13795	12523
Ensembl ID		ENSG00000099381	ENSG00000103507
Uniprot IDs		O15047	A0A024QZA9 O14874
PDB IDs		3S8S 3UVN 4EWR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?