ECE2 and CD86

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ECE2	CD86
Description		endothelin converting enzyme 2	CD86 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Methyltransferase Activity Metal Ion Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity
	Biological Process	Cell-cell Signaling Peptide Hormone Processing Methylation	Adaptive Immune Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Lymphotoxin A Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide
Pathways		Peptide ligand-binding receptors	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept
Diseases
GWAS		Body mass index ( 29273807) Major depressive disorder ( 22472876) Menarche (age at onset) ( 21102462)	Diffuse large B cell lymphoma ( 25261932) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 31604244 22190364 24076602 21833088 27386562) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)
Interacting Genes		5 interacting genes: CASP10 CD86 MTNR1A SYNE4 UBC	6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1
Entrez ID		9718	942
HPRD ID		09931	03011
Ensembl ID		ENSG00000145194	ENSG00000114013
Uniprot IDs		P0DPD6 P0DPD8	A0A0X9R4E0 A8K632 P42081
PDB IDs			1I85 1NCN 5YXK
Enriched GO Terms of Interacting Partners?
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