ULK2 and SYNGAP1

Number of citations of the paper that reports this interaction (PubMedID 15014045)
75

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid)

		ULK2	SYNGAP1
Description		unc-51 like autophagy activating kinase 2	synaptic Ras GTPase activating protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Cytosol Membrane Cytoplasmic Vesicle Membrane Phagophore Assembly Site Membrane	Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Glutamatergic Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	GTPase Activator Activity SH3 Domain Binding
	Biological Process	Autophagosome Assembly Autophagy Signal Transduction Regulation Of Autophagy Response To Starvation Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Autophagy Of Host Cells Involved In Interaction With Symbiont	MAPK Cascade Ras Protein Signal Transduction Pattern Specification Process Visual Learning Dendrite Development Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Maintenance Of Postsynaptic Specialization Structure
Pathways			Regulation of RAS by GAPs
Drugs
Diseases			Non-syndromic autosomal dominant mental retardation
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)
Interacting Genes		15 interacting genes: ATG14 DIXDC1 DUXAP9 EEF1B2 GABARAP GABARAPL2 LNX1 LUC7L2 NASP POLA2 SETDB1 SQSTM1 SYNGAP1 TNPO1 ZNF32	13 interacting genes: CAMK2A DLG3 DLG4 DLGAP4 GRIN1 GRIN2B GRIN2D KDR MPDZ PDGFRB TRIP6 ULK1 ULK2
Entrez ID		9706	8831
HPRD ID		10556	16018
Ensembl ID		ENSG00000083290	ENSG00000197283
Uniprot IDs		Q8IYT8	A0A1U9X8L0 B7ZCA0 Q96PV0
PDB IDs		6QAT 6QAU 6QAV
Enriched GO Terms of Interacting Partners?
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