SYNGAP1 and DLGAP4

Number of citations of the paper that reports this interaction (PubMedID 9620694)
153

Data Source:
HPRD (in vivo, two hybrid)

		SYNGAP1	DLGAP4
Description		synaptic Ras GTPase activating protein 1	DLG associated protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Glutamatergic Synapse	Plasma Membrane Neuromuscular Junction Glutamatergic Synapse Cholinergic Synapse Postsynaptic Specialization
	Molecular Function	GTPase Activator Activity SH3 Domain Binding	Protein Binding
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Pattern Specification Process Visual Learning Dendrite Development Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Maintenance Of Postsynaptic Specialization Structure	Signaling
Pathways		Regulation of RAS by GAPs	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases		Non-syndromic autosomal dominant mental retardation
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)
Interacting Genes		13 interacting genes: CAMK2A DLG3 DLG4 DLGAP4 GRIN1 GRIN2B GRIN2D KDR MPDZ PDGFRB TRIP6 ULK1 ULK2	15 interacting genes: BIN1 DLG1 DLG3 DLG4 EXOC4 GRIN1 GRIN2D PLP2 PPP1R1B SH3GL2 SHANK2 SHANK3 SORBS2 SYNGAP1 UBC
Entrez ID		8831	22839
HPRD ID		16018	16826
Ensembl ID		ENSG00000197283	ENSG00000080845
Uniprot IDs		A0A1U9X8L0 B7ZCA0 Q96PV0	A0A0B4J2C2 Q9Y2H0
PDB IDs
Enriched GO Terms of Interacting Partners?
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