SH3PXD2A and ADAM15

Number of citations of the paper that reports this interaction (PubMedID 16374509)
37

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro)

		SH3PXD2A	ADAM15
Description		SH3 and PX domains 2A	ADAM metallopeptidase domain 15
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Cytosol Cell Junction Cell Projection	Acrosomal Vesicle Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Motile Cilium Extracellular Exosome
	Molecular Function	Protease Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Superoxide Metabolic Process Extracellular Matrix Organization Positive Regulation Of Catalytic Activity Osteoclast Fusion	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Immune Response To Tumor Cell Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Male Gonad Development Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Receptor Binding Cellular Response To Phorbol 13-acetate 12-myristate Response To Hypobaric Hypoxia
Pathways		Invadopodia formation	Degradation of the extracellular matrix Invadopodia formation
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 28416822 29290336 29892015) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cutaneous malignant melanoma ( 26237428) Diisocyanate-induced asthma ( 25918132) Intraocular pressure ( 29617998) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Manganese levels ( 26025379) PR interval ( 30046033) Rheumatoid arthritis ( 30891314) Stroke ( 29531354) Waist circumference adjusted for body mass index ( 28552196) White matter hyperintensity burden ( 25663218)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chin dimples ( 27182965) General risk tolerance (MTAG) ( 30643258) Mosquito bite size ( 28199695) Prostate cancer ( 23535732) Systemic lupus erythematosus ( 28714469)
Interacting Genes		7 interacting genes: ADAM15 AFAP1L2 FASLG KHDRBS1 PAK2 SRC SVIL	32 interacting genes: ABL1 ARHGEF6 ARHGEF7 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1
Entrez ID		9644	8751
HPRD ID		10228	05674
Ensembl ID		ENSG00000107957	ENSG00000143537
Uniprot IDs		B3KPL1 Q5TCZ1	Q13444
PDB IDs		2DNU 2EGA 2EGC 2EKH
Enriched GO Terms of Interacting Partners?
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