SH3PXD2A and AFAP1L2

Number of citations of the paper that reports this interaction (PubMedID 26446840)
3

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SH3PXD2A	AFAP1L2
Description		SH3 and PX domains 2A	actin filament associated protein 1 like 2
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GO Annotations	Cellular Component	Podosome Cytosol Cell Junction Cell Projection	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protease Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding	SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity SH2 Domain Binding
	Biological Process	In Utero Embryonic Development Superoxide Metabolic Process Extracellular Matrix Organization Positive Regulation Of Catalytic Activity Osteoclast Fusion	Inflammatory Response Regulation Of Mitotic Cell Cycle Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways		Invadopodia formation
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 28416822 29290336 29892015) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cutaneous malignant melanoma ( 26237428) Diisocyanate-induced asthma ( 25918132) Intraocular pressure ( 29617998) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Manganese levels ( 26025379) PR interval ( 30046033) Rheumatoid arthritis ( 30891314) Stroke ( 29531354) Waist circumference adjusted for body mass index ( 28552196) White matter hyperintensity burden ( 25663218)	Cognitive performance ( 20125193) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Metabolite levels ( 23823483) Systolic blood pressure ( 29212154)
Interacting Genes		7 interacting genes: ADAM15 AFAP1L2 FASLG KHDRBS1 PAK2 SRC SVIL	10 interacting genes: ACD APP ATXN1L POT1 RASA1 SH3PXD2A SRC TERF1 TERF2 TINF2
Entrez ID		9644	84632
HPRD ID		10228	13902
Ensembl ID		ENSG00000107957	ENSG00000169129
Uniprot IDs		B3KPL1 Q5TCZ1	B7Z2Q0 Q8N4X5
PDB IDs		2DNU 2EGA 2EGC 2EKH	2COF
Enriched GO Terms of Interacting Partners?
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