RARG and NKX3-1

Number of citations of the paper that reports this interaction (PubMedID 18816836)
4

Data Source:
BioGRID (two hybrid)

		RARG	NKX3-1
Description		retinoic acid receptor gamma	NK3 homeobox 1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Integral Component Of Membrane RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Site Of DNA Damage
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Retinoid X Receptor Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Estrogen Receptor Activity Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Self-association Transcription Regulatory Region DNA Binding MADS Box Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Glandular Epithelial Cell Development Growth Plate Cartilage Chondrocyte Growth Transcription Initiation From RNA Polymerase II Promoter Multicellular Organism Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Size Hormone-mediated Signaling Pathway Anterior/posterior Pattern Specification Cell Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Response To Lipid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Steroid Hormone Mediated Signaling Pathway Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Organ Development Gland Development Canonical Wnt Signaling Pathway Face Development Bone Morphogenesis Epithelium Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Harderian Gland Development Cellular Response To Retinoic Acid Cellular Response To Leukemia Inhibitory Factor	Metanephros Development Somitogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organism Development Salivary Gland Development Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Differentiation Androgen Receptor Signaling Pathway Regulation Of Protein Localization Response To Testosterone Cellular Response To Drug Dorsal Aorta Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cell Division Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Mitotic Cell Cycle Arrest Negative Regulation Of Estrogen Receptor Binding Positive Regulation Of Androgen Secretion Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate SR11254 4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid CD564 Dodecyl-Alpha-D-Maltoside BMS184394 R667 LGD-1550 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid
Diseases			Prostate cancer
GWAS		Anthracycline-induced cardiotoxicity in childhood cancer ( 26237429) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)	Birth weight ( 31043758) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Prostate cancer ( 26443449) Prostate-specific antigen levels ( 28139693) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		32 interacting genes: ACY3 ARID1A HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 NCOA1 NCOA3 NCOR1 NCOR2 NEK9 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 PRIM1 PSMC5 RHPN2 RXRA RXRB RXRG S100A3 SMAD3 SMARCD3 SPHK1 TNIP1 ZNF576	32 interacting genes: AEN CCT7 CENPX CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 MT-ND4 PEBP1 PTMS RABL6 RARG RPL37A RPSA SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 TEX264 TOPORS TPT1 WDR77
Entrez ID		5916	4824
HPRD ID		01573	03620
Ensembl ID		ENSG00000172819	ENSG00000167034
Uniprot IDs		A8K3H3 B7Z4B4 F1D8P1 P13631	Q99801
PDB IDs		1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD 5M24 6FX0	2L9R
Enriched GO Terms of Interacting Partners?
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