MYOT and FLNC

Number of citations of the paper that reports this interaction (PubMedID 11038172)
41

Data Source:
HPRD (two hybrid, in vivo)

		MYOT	FLNC
Description		myotilin	filamin C
Image
GO Annotations	Cellular Component	Plasma Membrane Actin Cytoskeleton Z Disc Axon Sarcolemma Neuronal Cell Body	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere
	Molecular Function	Actin Binding Protein Binding Axon Guidance Receptor Activity Structural Constituent Of Muscle Alpha-actinin Binding	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding
	Biological Process	Muscle Contraction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Synapse Organization	Cell Junction Assembly Muscle Fiber Development
Pathways			Cell-extracellular matrix interactions
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Limb-girdle muscular dystrophy (LGMD)	Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Atrial fibrillation ( 30061737) Heart rate ( 23583979) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)	Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		13 interacting genes: ACTN1 ACTN2 APP AXIN1 FLNA FLNC GPRASP2 LRP12 NME7 ST7 TFG TRIM55 TRIM63	31 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		9499	2318
HPRD ID		04981	00018
Ensembl ID		ENSG00000120729	ENSG00000128591
Uniprot IDs		A0A0C4DFM5 B4DT68 Q9UBF9	Q14315 Q59H94
PDB IDs		2KDG 2KKQ	1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX
Enriched GO Terms of Interacting Partners?
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