FLNC and SYNPO2

Number of citations of the paper that reports this interaction (PubMedID 20554076)
18

Data Source:
BioGRID (two hybrid, pull down)

		FLNC	SYNPO2
Description		filamin C	synaptopodin 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere	Stress Fiber Nucleus Nucleoplasm Cytosol Focal Adhesion Actin Cytoskeleton Z Disc Intracellular Membrane-bounded Organelle Tethering Complex
	Molecular Function	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding	Actin Binding Protein Binding Protein Binding, Bridging Filamin Binding Muscle Alpha-actinin Binding Alpha-actinin Binding 14-3-3 Protein Binding
	Biological Process	Cell Junction Assembly Muscle Fiber Development	Autophagosome Assembly Positive Regulation Of Actin Filament Bundle Assembly Chaperone-mediated Autophagy
Pathways		Cell-extracellular matrix interactions
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Diastolic blood pressure ( 30224653) Epithelial ovarian cancer ( 25581431) Estimated glomerular filtration rate after 5 years in renal transplantation (donor effect) ( 30920136) Heel bone mineral density ( 30598549) IgE levels in asthmatics ( 23967269)
Interacting Genes		31 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2	6 interacting genes: ACTN2 CDK6 FLNA FLNC YWHAG YWHAZ
Entrez ID		2318	171024
HPRD ID		00018	15456
Ensembl ID		ENSG00000128591	ENSG00000172403
Uniprot IDs		Q14315 Q59H94	B4E258 Q9UMS6
PDB IDs		1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX
Enriched GO Terms of Interacting Partners?
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