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HAND2 and PRKCA
Number of citations of the paper that reports this interaction (PubMedID
14636580
)
45
Data Source:
HPRD
(in vivo, in vitro)
HAND2
PRKCA
Description
heart and neural crest derivatives expressed 2
protein kinase C alpha
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Transcription Factor Complex
Protein-containing Complex
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Mitochondrial Membrane
Alphav-beta3 Integrin-PKCalpha Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
AT DNA Binding
Protein Binding
Transcription Factor Binding
Activating Transcription Factor Binding
Protein Homodimerization Activity
Transcription Regulatory Region DNA Binding
E-box Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Integrin Binding
Protein Binding
ATP Binding
Zinc Ion Binding
Enzyme Binding
Histone Kinase Activity (H3-T6 Specific)
Biological Process
Angiogenesis
In Utero Embryonic Development
Heart Looping
Suckling Behavior
Cardiac Right Ventricle Formation
Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Apoptotic Process Involved In Heart Morphogenesis
Noradrenergic Neuron Differentiation
Regulation Of Transcription By RNA Polymerase II
Heart Development
Adult Heart Development
Mesenchymal Cell Proliferation
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Developmental Process
Regulation Of Tissue Remodeling
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Tongue Development
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Sympathetic Nervous System Development
Thymus Development
Peripheral Nervous System Neuron Development
Cartilage Morphogenesis
Coronary Artery Morphogenesis
Visceral Serous Pericardium Development
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Cell Proliferation Involved In Outflow Tract Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of P38MAPK Cascade
Primary Palate Development
Positive Regulation Of Transcription Regulatory Region DNA Binding
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process
Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Desmosome Assembly
Protein Phosphorylation
Mitotic Nuclear Envelope Disassembly
Cell Adhesion
Axon Guidance
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cardiac Muscle Hypertrophy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Platelet Activation
Positive Regulation Of Cell Migration
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Glial Cell Apoptotic Process
Histone H3-T6 Phosphorylation
Intracellular Signal Transduction
ERBB2 Signaling Pathway
Regulation Of MRNA Stability
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Bone Resorption
Positive Regulation Of Cell Adhesion
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Insulin Secretion
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Interleukin-1
Regulation Of Platelet Aggregation
Apoptotic Signaling Pathway
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Dense Core Granule Biogenesis
Pathways
Transcriptional regulation by RUNX2
Calmodulin induced events
Disinhibition of SNARE formation
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
RHO GTPases Activate NADPH Oxidases
Response to elevated platelet cytosolic Ca2+
RET signaling
ROBO receptors bind AKAP5
ROBO receptors bind AKAP5
Drugs
Phosphatidyl serine
Vitamin E
Tamoxifen
Ingenol Mebutate
Midostaurin
Ellagic Acid
Diseases
GWAS
Atrial fibrillation (
28416822
30061737
29892015
)
Chin dimples (
27182965
)
Early onset atrial fibrillation (
28460022
)
Epstein-Barr virus copy number in lymphoblastoid cell lines (
28654678
)
Bipolar disorder (
31043756
)
Blood protein levels (
28240269
)
Coronary artery calcification (
23870195
)
Feeling guilty (
29500382
)
Food addiction (
27106561
)
Gout (
22179738
)
Height (
22021425
)
Heschl's gyrus morphology (
25130324
)
Lateral occipital cortex volume (
31530798
)
Neuroticism (
29255261
)
Percent glycated albumin (
29844224
)
Possible neuropathic pain in post total joint replacement surgery for osteoarthritis (
28051079
)
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
QRS complex (12-leadsum) (
27659466
)
QRS complex (Sokolow-Lyon) (
27659466
)
QRS duration (
27577874
30012220
27659466
)
QT interval (
29213071
24952745
)
Systolic blood pressure (
31170924
)
Total glycated albumin levels (
29844224
)
Interacting Genes
15 interacting genes:
CENPB
COPS5
DNMT3L
EP300
GATA4
HAND1
HEY2
HEYL
NPM1
PHOX2A
PPP2R5D
PRKACA
PRKCA
TCF3
TCF4
229 interacting genes:
ACTA1
ADAP1
ADCY5
ADD1
ADD3
ADRA1B
AFAP1
AKAP12
AKAP5
ANXA2
ANXA7
APLP2
ARHGEF1
ATP1A1
ATP2B1
ATP2B2
AVPR1A
BCL2
BTG2
BTK
C1QBP
CACYBP
CASR
CAVIN2
CBL
CD163
CD5
CD9
CDC42
CDKN2A
CFTR
CHAT
CISH
CORO1B
CREM
CYP3A4
CYTH2
DDX5
DGKD
DGKZ
DLG4
DLX3
DNM1
DVL2
EDF1
EEF1D
EGFR
EGLN2
EIF2S1
EIF4E
EIF4EBP1
ELAVL1
ENTPD5
EP300
EWSR1
EZR
F11R
FAS
FBXO25
FBXO7
FCGR2B
FCGR3A
FLNA
FLNC
FSCN1
GABRB3
GABRG2
GABRR1
GABRR2
GFAP
GFPT1
GJA1
GJB1
GLI3
GMFB
GNA12
GNA15
GPM6A
GRIA1
GRIA2
GRIA4
GRIN1
GRIN2A
GRIN2B
GRK2
GRM1
GRM5
GSK3A
GSK3B
H1-1
H1-2
H1-3
H1-4
H1-5
H1-6
H3-4
H3C1
HABP4
HAND1
HAND2
HES1
HLA-A
HMGA1
HMGA2
HMGB1
HMGN1
HMGN2
HR
HSP90AA1
HSPA1A
HSPB8
IKBKB
INSR
ITGB1
ITGB2
ITGB4
ITPKA
ITPKB
KCNE1
KCNE4
KCNQ2
KIT
KLF5
KRT18
LCK
LMNA
LMNB1
MAPKAP1
MAPT
MARCKS
MBP
MGMT
MTOR
MYLK
MYOD1
NCF1
NF2
NFATC1
NFE2L2
NFKBIA
NOS1
NOXA1
NR1H2
NRGN
NUMB
OGG1
OPRD1
PA2G4
PAM
PDLIM7
PEA15
PEBP1
PFKFB1
PFKFB2
PHB2
PICK1
PLA2G4A
PLCB1
PLD1
PLD2
POLB
PPARA
PPARG
PPM1A
PPP1R14A
PRKACA
PRKCZ
PRKG1
PSMB4
PTGIR
PTPN11
PTPN12
PTPN6
RAC1
RACK1
RAF1
RALBP1
RARA
RBCK1
RGS19
RGS2
RGS7
RHO
RHOA
RNF31
RPL10
RRAD
SACM1L
SCRIB
SCTR
SDC2
SDC4
SELL
SEMG1
SEMG2
SHC1
SLC1A1
SLC6A9
SLC9A3R1
SLC9A3R2
SMURF1
SNAP23
SNAP25
SPAG1
SPP1
SRC
STXBP1
STXBP3
SYK
TBXA2R
TEP1
TERT
THOC5
TIAM1
TNNI3
TNNT2
TNP1
TNP2
TOP2A
TP53
TRIM29
TRIM41
TRPC3
TRPV6
VCL
VTN
XK
YWHAG
YWHAZ
Entrez ID
9464
5578
HPRD ID
03872
01498
Ensembl ID
ENSG00000164107
ENSG00000154229
Uniprot IDs
P61296
L7RSM7
P17252
Q7Z727
PDB IDs
2ELI
3IW4
4DNL
4RA4
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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