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PRKCA and ANXA2
Number of citations of the paper that reports this interaction (PubMedID
2946940
)
39
Data Source:
HPRD
(in vivo, in vitro)
PRKCA
ANXA2
Description
protein kinase C alpha
annexin A2
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Mitochondrial Membrane
Alphav-beta3 Integrin-PKCalpha Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Ruffle
Extracellular Region
Basement Membrane
Extracellular Space
Cell
Nucleus
Cytoplasm
Lysosomal Membrane
Endosome
Early Endosome
Lipid Droplet
Cytosol
Plasma Membrane
Adherens Junction
Cell Cortex
Cell Surface
Membrane
Basolateral Plasma Membrane
Extrinsic Component Of Plasma Membrane
Midbody
Late Endosome Membrane
Vesicle
Azurophil Granule Lumen
Myelin Sheath Adaxonal Region
Sarcolemma
Melanosome
Schmidt-Lanterman Incisure
Macropinosome
Membrane Raft
Perinuclear Region Of Cytoplasm
Collagen-containing Extracellular Matrix
Extracellular Exosome
AnxA2-p11 Complex
PCSK9-AnxA2 Complex
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Integrin Binding
Protein Binding
ATP Binding
Zinc Ion Binding
Enzyme Binding
Histone Kinase Activity (H3-T6 Specific)
Phosphatidylserine Binding
Protease Binding
RNA Binding
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calcium-dependent Phospholipid Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Cytoskeletal Protein Binding
Rab GTPase Binding
Phospholipase A2 Inhibitor Activity
Identical Protein Binding
S100 Protein Binding
Virion Binding
Calcium-dependent Protein Binding
Cadherin Binding Involved In Cell-cell Adhesion
Molecular Function Regulator
Biological Process
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Desmosome Assembly
Protein Phosphorylation
Mitotic Nuclear Envelope Disassembly
Cell Adhesion
Axon Guidance
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cardiac Muscle Hypertrophy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Platelet Activation
Positive Regulation Of Cell Migration
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Glial Cell Apoptotic Process
Histone H3-T6 Phosphorylation
Intracellular Signal Transduction
ERBB2 Signaling Pathway
Regulation Of MRNA Stability
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Bone Resorption
Positive Regulation Of Cell Adhesion
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Insulin Secretion
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Interleukin-1
Regulation Of Platelet Aggregation
Apoptotic Signaling Pathway
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Dense Core Granule Biogenesis
Angiogenesis
Membrane Raft Assembly
Positive Regulation Of Receptor Recycling
Vesicle Budding From Membrane
Body Fluid Secretion
Viral Process
Positive Regulation Of Vesicle Fusion
Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Interleukin-12-mediated Signaling Pathway
Osteoclast Development
Negative Regulation Of Catalytic Activity
Neutrophil Degranulation
Positive Regulation Of Vacuole Organization
Negative Regulation Of Development Of Symbiont Involved In Interaction With Host
Regulation Of Cytosolic Calcium Ion Concentration
Catabolism By Host Of Symbiont Protein
Negative Regulation By Host Of Symbiont Molecular Function
Calcium Ion Transmembrane Transport
Response To Thyroid Hormone
Cell-cell Adhesion
Positive Regulation Of Low-density Lipoprotein Particle Clearance
Positive Regulation Of Low-density Lipoprotein Particle Receptor Binding
Positive Regulation Of Low-density Lipoprotein Receptor Activity
Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways
Calmodulin induced events
Disinhibition of SNARE formation
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
RHO GTPases Activate NADPH Oxidases
Response to elevated platelet cytosolic Ca2+
RET signaling
ROBO receptors bind AKAP5
ROBO receptors bind AKAP5
Smooth Muscle Contraction
Neutrophil degranulation
Dissolution of Fibrin Clot
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Phosphatidyl serine
Vitamin E
Tamoxifen
Ingenol Mebutate
Midostaurin
Ellagic Acid
Tenecteplase
Artenimol
Diseases
GWAS
Bipolar disorder (
31043756
)
Blood protein levels (
28240269
)
Coronary artery calcification (
23870195
)
Feeling guilty (
29500382
)
Food addiction (
27106561
)
Gout (
22179738
)
Height (
22021425
)
Heschl's gyrus morphology (
25130324
)
Lateral occipital cortex volume (
31530798
)
Neuroticism (
29255261
)
Percent glycated albumin (
29844224
)
Possible neuropathic pain in post total joint replacement surgery for osteoarthritis (
28051079
)
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
QRS complex (12-leadsum) (
27659466
)
QRS complex (Sokolow-Lyon) (
27659466
)
QRS duration (
27577874
30012220
27659466
)
QT interval (
29213071
24952745
)
Systolic blood pressure (
31170924
)
Total glycated albumin levels (
29844224
)
Asthma (age of onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Blood protein levels (
30072576
28240269
)
Night sleep phenotypes (
27126917
)
Type 2 diabetes (
25102180
)
Interacting Genes
229 interacting genes:
ACTA1
ADAP1
ADCY5
ADD1
ADD3
ADRA1B
AFAP1
AKAP12
AKAP5
ANXA2
ANXA7
APLP2
ARHGEF1
ATP1A1
ATP2B1
ATP2B2
AVPR1A
BCL2
BTG2
BTK
C1QBP
CACYBP
CASR
CAVIN2
CBL
CD163
CD5
CD9
CDC42
CDKN2A
CFTR
CHAT
CISH
CORO1B
CREM
CYP3A4
CYTH2
DDX5
DGKD
DGKZ
DLG4
DLX3
DNM1
DVL2
EDF1
EEF1D
EGFR
EGLN2
EIF2S1
EIF4E
EIF4EBP1
ELAVL1
ENTPD5
EP300
EWSR1
EZR
F11R
FAS
FBXO25
FBXO7
FCGR2B
FCGR3A
FLNA
FLNC
FSCN1
GABRB3
GABRG2
GABRR1
GABRR2
GFAP
GFPT1
GJA1
GJB1
GLI3
GMFB
GNA12
GNA15
GPM6A
GRIA1
GRIA2
GRIA4
GRIN1
GRIN2A
GRIN2B
GRK2
GRM1
GRM5
GSK3A
GSK3B
H1-1
H1-2
H1-3
H1-4
H1-5
H1-6
H3-4
H3C1
HABP4
HAND1
HAND2
HES1
HLA-A
HMGA1
HMGA2
HMGB1
HMGN1
HMGN2
HR
HSP90AA1
HSPA1A
HSPB8
IKBKB
INSR
ITGB1
ITGB2
ITGB4
ITPKA
ITPKB
KCNE1
KCNE4
KCNQ2
KIT
KLF5
KRT18
LCK
LMNA
LMNB1
MAPKAP1
MAPT
MARCKS
MBP
MGMT
MTOR
MYLK
MYOD1
NCF1
NF2
NFATC1
NFE2L2
NFKBIA
NOS1
NOXA1
NR1H2
NRGN
NUMB
OGG1
OPRD1
PA2G4
PAM
PDLIM7
PEA15
PEBP1
PFKFB1
PFKFB2
PHB2
PICK1
PLA2G4A
PLCB1
PLD1
PLD2
POLB
PPARA
PPARG
PPM1A
PPP1R14A
PRKACA
PRKCZ
PRKG1
PSMB4
PTGIR
PTPN11
PTPN12
PTPN6
RAC1
RACK1
RAF1
RALBP1
RARA
RBCK1
RGS19
RGS2
RGS7
RHO
RHOA
RNF31
RPL10
RRAD
SACM1L
SCRIB
SCTR
SDC2
SDC4
SELL
SEMG1
SEMG2
SHC1
SLC1A1
SLC6A9
SLC9A3R1
SLC9A3R2
SMURF1
SNAP23
SNAP25
SPAG1
SPP1
SRC
STXBP1
STXBP3
SYK
TBXA2R
TEP1
TERT
THOC5
TIAM1
TNNI3
TNNT2
TNP1
TNP2
TOP2A
TP53
TRIM29
TRIM41
TRPC3
TRPV6
VCL
VTN
XK
YWHAG
YWHAZ
43 interacting genes:
ACTA1
APOH
APP
CCDC32
CD99
CDC42
CEACAM1
CTSB
CTSS
DYSF
GRB2
HMGA1
LGALS13
LYPLA1
MAP3K4
MYOC
NOD2
OGDH
PHB
PLA1A
PLA2G4A
PLAT
PLG
POT1
PRKCA
PRKCB
PTEN
RPS2
S100A10
S100A4
S100A6
SMN1
SNX17
SOS1
SRC
STAT6
TENT2
TERF1
TERT
TP53
TRPV5
YWHAQ
ZBTB4
Entrez ID
5578
302
HPRD ID
01498
01061
Ensembl ID
ENSG00000154229
ENSG00000182718
Uniprot IDs
L7RSM7
P17252
Q7Z727
A0A024R5Z7
P07355
PDB IDs
2ELI
3IW4
4DNL
4RA4
1W7B
1XJL
2HYU
2HYV
2HYW
4DRW
4FTG
4HRH
5LPU
5LPX
5LQ0
5LQ2
5N7D
5N7F
5N7G
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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