HOMER2 and ITPR1

Number of citations of the paper that reports this interaction (PubMedID 9808459)
230

Data Source:
HPRD (in vivo, in vitro)

		HOMER2	ITPR1
Description		homer scaffold protein 2	inositol 1,4,5-trisphosphate receptor type 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Junction Dendrite Stereocilium Tip Neuron Projection Neuronal Cell Body Apical Part Of Cell Glutamatergic Synapse	Cell Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse
	Molecular Function	Actin Binding Protein Binding Protein Domain Specific Binding GKAP/Homer Scaffold Activity G Protein-coupled Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium-release Channel Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels
	Biological Process	G Protein-coupled Glutamate Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Negative Regulation Of Interleukin-2 Production Calcium-mediated Signaling Using Intracellular Calcium Source Behavioral Response To Cocaine Chemical Homeostasis Within A Tissue Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry	Response To Hypoxia Calcium Ion Transport Signal Transduction Post-embryonic Development Regulation Of Autophagy Platelet Activation Endoplasmic Reticulum Calcium Ion Homeostasis Epithelial Fluid Transport Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction
Pathways		Neurexins and neuroligins Neurexins and neuroligins	PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway cGMP effects Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Caffeine 1D-myo-inositol 1,4,5-trisphosphate Glycerin
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Tourette syndrome ( 30818990)	Airflow obstruction ( 22837378) Breast cancer ( 23535729) Calcium levels ( 29403010) Diabetic kidney disease ( 26305897) Gamma glutamyl transferase levels ( 29403010) Hand grip strength ( 29691431) Lead levels ( 26025379) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Systolic blood pressure ( 26969751) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Uterine fibroids ( 30194396) Weight ( 28552196) Western dietary pattern ( 28644415)
Interacting Genes		12 interacting genes: AGAP2 APP DBN1 GRM1 ITPR1 KPNA2 LZTS2 PJA1 RYR1 SMURF1 UBXN1 VKORC1	30 interacting genes: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 BRCA1 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 IRAG1 ITPR3 ITPRIP LYN PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4
Entrez ID		9455	3708
HPRD ID		07269	00925
Ensembl ID		ENSG00000103942	ENSG00000150995
Uniprot IDs		Q9NSB8	A0A3B3ITU8 A0A3F2YNW8 B4DER3 B4DGH1 Q14643 Q59H91
PDB IDs
Enriched GO Terms of Interacting Partners?
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