ITPR1 and PRKG1

Number of citations of the paper that reports this interaction (PubMedID 8132598)
36

Data Source:
HPRD (in vitro, in vivo)

		ITPR1	PRKG1
Description		inositol 1,4,5-trisphosphate receptor type 1	protein kinase cGMP-dependent 1
Image		No pdb structure
GO Annotations	Cellular Component	Cell Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium-release Channel Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels	Protein Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process	Response To Hypoxia Calcium Ion Transport Signal Transduction Post-embryonic Development Regulation Of Autophagy Platelet Activation Endoplasmic Reticulum Calcium Ion Homeostasis Epithelial Fluid Transport Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction	Neuron Migration Protein Phosphorylation Signal Transduction Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Platelet Aggregation Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway cGMP effects Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Ca2+ pathway
Drugs		Caffeine 1D-myo-inositol 1,4,5-trisphosphate Glycerin
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Airflow obstruction ( 22837378) Breast cancer ( 23535729) Calcium levels ( 29403010) Diabetic kidney disease ( 26305897) Gamma glutamyl transferase levels ( 29403010) Hand grip strength ( 29691431) Lead levels ( 26025379) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Systolic blood pressure ( 26969751) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Uterine fibroids ( 30194396) Weight ( 28552196) Western dietary pattern ( 28644415)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol misuse (trauma interaction) ( 28265120) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Chlamydia trachomatis seropositivity ( 29967566) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Gait rhythm ( 26219847) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		30 interacting genes: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 BRCA1 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 IRAG1 ITPR3 ITPRIP LYN PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4	35 interacting genes: ANXA7 AR CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRPC3 VASP WDR77 ZNF646
Entrez ID		3708	5592
HPRD ID		00925	08910
Ensembl ID		ENSG00000150995	ENSG00000185532
Uniprot IDs		A0A3B3ITU8 A0A3F2YNW8 B4DER3 B4DGH1 Q14643 Q59H91	Q13976
PDB IDs			1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T
Enriched GO Terms of Interacting Partners?
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