LPXN and PLEKHH2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		LPXN	PLEKHH2
Description		leupaxin	pleckstrin homology, MyTH4 and FERM domain containing H2
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body Lamellipodium Cortical Actin Cytoskeleton
	Molecular Function	Transcription Coregulator Activity Protein Binding Metal Ion Binding	Actin Binding Protein Binding Identical Protein Binding
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of B Cell Receptor Signaling Pathway Protein-containing Complex Assembly Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Actin Filament Depolymerization
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640) Pulse pressure ( 30578418) Ulcerative colitis ( 28067908)	Coronary artery disease ( 29212778) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767)
Interacting Genes		27 interacting genes: GIT1 HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 MAP2K7 MAPK6 NDN NR3C1 PHF21A PLEKHH2 PLEKHN1 PLSCR4 POM121 PTK2 PTK2B PTPN12 RUNX1T1 SFI1 TXLNB VCL ZNF175 ZNF426	1 interacting genes: LPXN
Entrez ID		9404	130271
HPRD ID		05651	15149
Ensembl ID		ENSG00000110031	ENSG00000152527
Uniprot IDs		B7Z5P7 O60711	Q8IVE3
PDB IDs		1X3H 4XEF 4XEK 4XEV
Enriched GO Terms of Interacting Partners?
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