ACVRL1 and TGFBRAP1

Number of citations of the paper that reports this interaction (PubMedID 11278302)
14

Data Source:
HPRD (in vivo)

		ACVRL1	TGFBRAP1
Description		activin A receptor like type 1	transforming growth factor beta receptor associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Dendrite Neuronal Cell Body Receptor Complex BMP Receptor Complex	Early Endosome Membrane CORVET Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Protein Kinase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding BMP Receptor Activity	Transforming Growth Factor Beta Receptor Binding Protein Binding SMAD Binding
	Biological Process	Angiogenesis Response To Hypoxia In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Maturation Blood Vessel Remodeling Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Endocardial Cushion Morphogenesis Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Phosphorylation Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Circulation Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Dorsal Aorta Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Focal Adhesion Assembly Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Endothelial Tube Morphogenesis Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Endocardial Cushion To Mesenchymal Transition Negative Regulation Of DNA Biosynthetic Process	Regulation Of Transcription, DNA-templated Intracellular Protein Transport Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Endosome To Lysosome Transport Vesicle-mediated Transport Endosomal Vesicle Fusion
Pathways		Signaling by BMP
Drugs		ATP
Diseases		Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Hematocrit ( 29403010) Hemoglobin ( 29403010) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Plateletcrit ( 27863252) Urate levels ( 23263486) White blood cell count ( 27863252)	AIDS ( 19754311) Body mass index ( 26426971) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Menarche (age at onset) ( 27182965) Obesity-related traits ( 23251661) Preeclampsia ( 23551011)
Interacting Genes		13 interacting genes: ACVR2A BAMBI CSNK2B FKBP1A GDF2 SMAD1 SNX6 TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBRAP1 XIAP	10 interacting genes: ACVR1B ACVR2B ACVRL1 ALOX5 BMPR1A EIF4E2 SMAD2 SMAD4 TGFBR1 TGFBR2
Entrez ID		94	9392
HPRD ID		03181	06948
Ensembl ID		ENSG00000139567	ENSG00000135966
Uniprot IDs		A0A0S2Z310 P37023	Q8WUH2
PDB IDs		2LCR 3MY0 4FAO
Enriched GO Terms of Interacting Partners?
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