PLAA and PLA2G1B

Number of citations of the paper that reports this interaction (PubMedID 2052621)
19

Data Source:
HPRD (in vitro)

		PLAA	PLA2G1B
Description		phospholipase A2 activating protein	phospholipase A2 group IB
Image
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Cell Junction Synapse Extracellular Exosome	Extracellular Region Extracellular Space Cell Cell Surface Secretory Granule
	Molecular Function	Protein Binding Phospholipase A2 Activator Activity Ubiquitin Binding	Phospholipase A2 Activity Signaling Receptor Binding Calcium Ion Binding Bile Acid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	Phospholipid Metabolic Process Prostaglandin Metabolic Process Inflammatory Response Signal Transduction Ubiquitin Recycling Macroautophagy Positive Regulation Of Phospholipase A2 Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Dendrite Extension Positive Regulation Of Neuron Migration	Activation Of MAPK Activity Innate Immune Response In Mucosa Neutrophil Mediated Immunity Fatty Acid Biosynthetic Process Phosphatidic Acid Biosynthetic Process Actin Filament Organization Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Lipid Catabolic Process Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Activation Of Phospholipase A2 Activity Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glucose Import Phosphatidylcholine Metabolic Process Positive Regulation Of Fibroblast Proliferation Arachidonic Acid Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways			Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs			Sulfasalazine Hexane-1,6-Diol N-Tridecanoic Acid Cholic Acid P-Anisic Acid Heptanoic Acid 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine Pyruvaldehyde Lpc-Ether Niflumic Acid PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Metabolite levels ( 23823483) Schizophrenia ( 20185149)	Bipolar disorder ( 31043756)
Interacting Genes		6 interacting genes: HDAC6 KPNA4 PLA2G1B UBC UBXN1 VCP	5 interacting genes: BGN CSF3R PLA2G2A PLAA SOCS2
Entrez ID		9373	5319
HPRD ID		04850	01396
Ensembl ID		ENSG00000137055	ENSG00000170890
Uniprot IDs		Q9Y263	P04054
PDB IDs		2K89 2K8A 2K8B 2K8C 3EBB	1YSK 3ELO
Enriched GO Terms of Interacting Partners?
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