PLA2G1B and CSF3R

Number of citations of the paper that reports this interaction (PubMedID 14557262)
4

Data Source:
HPRD (in vitro)

		PLA2G1B	CSF3R
Description		phospholipase A2 group IB	colony stimulating factor 3 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Cell Surface Secretory Granule	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex
	Molecular Function	Phospholipase A2 Activity Signaling Receptor Binding Calcium Ion Binding Bile Acid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Granulocyte Colony-stimulating Factor Binding
	Biological Process	Activation Of MAPK Activity Innate Immune Response In Mucosa Neutrophil Mediated Immunity Fatty Acid Biosynthetic Process Phosphatidic Acid Biosynthetic Process Actin Filament Organization Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Lipid Catabolic Process Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Activation Of Phospholipase A2 Activity Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glucose Import Phosphatidylcholine Metabolic Process Positive Regulation Of Fibroblast Proliferation Arachidonic Acid Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Defense Response Cell Adhesion Signal Transduction Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Regulation Of Myeloid Cell Differentiation Amelogenesis
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Other interleukin signaling Transcriptional regulation of granulopoiesis
Drugs		Sulfasalazine Hexane-1,6-Diol N-Tridecanoic Acid Cholic Acid P-Anisic Acid Heptanoic Acid 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine Pyruvaldehyde Lpc-Ether Niflumic Acid PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL	Pegfilgrastim Filgrastim FavId Lenograstim
Diseases
GWAS		Bipolar disorder ( 31043756)	Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Iron status biomarkers (total iron binding capacity) ( 28334935) Lymphocyte percentage of white cells ( 27863252) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 29403010 27863252)
Interacting Genes		5 interacting genes: BGN CSF3R PLA2G2A PLAA SOCS2	19 interacting genes: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2
Entrez ID		5319	1441
HPRD ID		01396	00737
Ensembl ID		ENSG00000170890	ENSG00000119535
Uniprot IDs		P04054	Q99062
PDB IDs		1YSK 3ELO	1AZ7 2D9Q
Enriched GO Terms of Interacting Partners?
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