NRXN3 and NLGN2

Number of citations of the paper that reports this interaction (PubMedID 8576240)
152

Data Source:
BioGRID (pull down)

		NRXN3	NLGN2
Description		neurexin 3	neuroligin 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Cell Junction Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Inhibitory Synapse Spanning Component Of Membrane Glycinergic Synapse Dopaminergic Synapse Symmetric, GABA-ergic, Inhibitory Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	Signaling Receptor Activity Neurexin Family Protein Binding Identical Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Neuron Cell-cell Adhesion Axon Guidance Learning Adult Behavior Social Behavior Vocalization Behavior	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Sensory Perception Of Pain Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Locomotory Exploration Behavior Cell-cell Junction Maintenance Synaptic Vesicle Endocytosis Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Terminal Button Organization Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Postsynaptic Density Protein 95 Clustering Positive Regulation Of Inhibitory Postsynaptic Potential Cell-cell Adhesion Presynapse Assembly Positive Regulation Of Protein Localization To Synapse Inhibitory Synapse Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering
Pathways		Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 26865924 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Bone mineral density (hip) ( 30172743) Chronotype ( 30696823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Electrodermal activity ( 25387706) Figural/spatial cognitive ability ( 31620175) Hip circumference ( 25673412) JT interval (sulfonylurea treatment interaction) ( 27958378) Medial orbital frontal cortex volume ( 31530798) Normal facial asymmetry (angle of deformation score) ( 30631343) Obesity ( 23563607 21552555) Objective response to lithium treatment in bipolar disorder ( 26503763) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Proliferative diabetic retinopathy in type 2 diabetes ( 29739359) Response to antidepressants (symptom improvement) ( 29160301) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Tea consumption ( 31046077) Type 2 diabetes ( 28566273 30054458 30297969) Underweight status ( 25133637) Urinary sodium excretion ( 31409800) Waist circumference ( 19557197 25673412) Waist-hip ratio ( 25673412) Weight ( 28552196)	Blood protein levels ( 30072576) Uterine fibroids ( 30194396)
Interacting Genes		6 interacting genes: AFDN CASK DNAJC5 NLGN1 NLGN2 NLGN3	7 interacting genes: DLG2 DLG3 DLG4 NRXN1 NRXN2 NRXN3 PATJ
Entrez ID		9369	57555
HPRD ID		08989	07348
Ensembl ID		ENSG00000021645	ENSG00000169992
Uniprot IDs		A0A0U1RRJ0 Q9HDB5 Q9Y4C0	Q8NFZ4
PDB IDs			5XEQ
Enriched GO Terms of Interacting Partners?
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