MYOCD and MRTFA

Number of citations of the paper that reports this interaction (PubMedID 14970199)
65

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		MYOCD	MRTFA
Description		myocardin	myocardin related transcription factor A
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coactivator Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Binding R-SMAD Binding	Transcription Coactivator Activity Actin Binding Actin Monomer Binding Protein Binding Leucine Zipper Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth By Extracellular Stimulus Vasculogenesis Response To Hypoxia Cardiac Ventricle Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiocyte Differentiation Regulation Of Histone Acetylation Vascular Smooth Muscle Cell Differentiation Positive Regulation Of DNA Binding Cellular Component Maintenance Regulation Of Myoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Lung Alveolus Development Digestive Tract Development Positive Regulation Of DNA-binding Transcription Factor Activity Smooth Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Uterus Development Urinary Bladder Development Ductus Arteriosus Closure Negative Regulation Of Amyloid-beta Clearance Regulation Of Phenotypic Switching Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Differentiation	Positive Regulation Of Transcription Via Serum Response Element Binding Actin Cytoskeleton Organization Wound Healing, Spreading Of Cells Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation
Pathways			SUMOylation of transcription cofactors RHO GTPases Activate Formins
Drugs			LATRUNCULIN B
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Metabolite levels ( 23823483) PR interval ( 30679814 30046033) QRS duration ( 31251759) Systolic blood pressure change trajectories ( 27980656) Testosterone levels ( 22675492)
Interacting Genes		11 interacting genes: GOPC GSK3B KDM3A MAMSTR MRTFA MYOD1 SMAD2 SMAD3 SMARCA4 SRF STUB1	9 interacting genes: KDM3A MRTFB MVP MYOCD NCOA3 SMARCA4 SRF SUMO1 UBE2I
Entrez ID		93649	57591
HPRD ID		09362	10445
Ensembl ID		ENSG00000141052	ENSG00000196588
Uniprot IDs		Q8IZQ8	A0A087WVL2 A4FUJ8 E7ER32 Q969V6 W0Z7M9
PDB IDs			2KVU 2KW9
Enriched GO Terms of Interacting Partners?
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