VAV2 and PPM1B

Number of citations of the paper that reports this interaction (PubMedID 18654987)
16

Data Source:
BioGRID (two hybrid)

		VAV2	PPM1B
Description		vav guanine nucleotide exchange factor 2	protein phosphatase, Mg2+/Mn2+ dependent 1B
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GO Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleus Nucleolus Cytosol Membrane
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding
	Biological Process	Angiogenesis Signal Transduction G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Size Cell Migration Lamellipodium Assembly Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction	Protein Dephosphorylation N-terminal Protein Myristoylation Negative Regulation Of Interferon-beta Production Peptidyl-threonine Dephosphorylation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Defense Response To Virus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442) Corneal astigmatism ( 30306274) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Multiple sclerosis ( 20598377) Pre-treatment viral load in HIV-1 infection ( 31219150) vWF and FVIII levels ( 21810271)	Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Height ( 23563607 31562340) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		64 interacting genes: ARIH1 BIRC6 BOD1L1 BRDT BZW1 CAV1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 FNTA FUCA1 FYN GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MED21 MRGBP NCKAP5 NEK3 NUP214 PHF10 PNMA1 POGZ PPM1B PRLR RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 STOM SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	19 interacting genes: AATK CDK2 CDK6 ECHS1 EGFR ERBB3 ERBB4 IKBKB IKBKG KDR MAP3K7 MSN PPARG PTK7 ROR1 ROR2 RYK SIRPA VAV2
Entrez ID		7410	5495
HPRD ID		02694	04796
Ensembl ID		ENSG00000160293	ENSG00000138032
Uniprot IDs		P52735	O75688
PDB IDs		2DLZ 2DM1 2LNW 2LNX 4ROJ	2P8E
Enriched GO Terms of Interacting Partners?
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