LDHAL6B and APPL2

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		LDHAL6B	APPL2
Description		lactate dehydrogenase A like 6B	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrial Matrix	Ruffle Nucleus Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Macropinosome Extracellular Exosome
	Molecular Function	L-lactate Dehydrogenase Activity Protein Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Carbohydrate Metabolic Process Pyruvate Metabolic Process Oxidation-reduction Process	Diet Induced Thermogenesis Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Pyruvate metabolism
Drugs		NADH
Diseases
GWAS			Mosquito bite size ( 28199695)
Interacting Genes		6 interacting genes: APPL2 HSH2D PRMT5 PRMT6 SOCS4 SUV39H1	27 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 DOK3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RPL36 RUVBL2 SUV39H2 TINF2 TSC1
Entrez ID		92483	55198
HPRD ID		13981	06945
Ensembl ID		ENSG00000171989	ENSG00000136044
Uniprot IDs		A0A140VJM9 Q9BYZ2	Q8NEU8
PDB IDs			4H8S 5C5B
Enriched GO Terms of Interacting Partners?
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